Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.44 |
| ▸ | THRB | P10828 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | TTR | P02766 | 2/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | PTPRC | P08575 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4190272 | 0.81 | NR4A2 (0.51) | MAPTALDH1A1LMNAKDM4EMEN1 | |
| SCHEMBL16224285 | 0.71 | MAPT (0.69) | MAPTALDH1A1LMNAL3MBTL1KDM4E | |
| SCHEMBL71118 | 0.70 | MAPT (0.74) | MAPTALDH1A1LMNAL3MBTL1KDM4E | |
| SCHEMBL29568790 | 0.70 | MAPT (0.74) | MAPTALDH1A1LMNAL3MBTL1KDM4E | |
| SCHEMBL30808237 | 0.69 | ALDH1A1 (0.85) | MAPTALDH1A1LMNAL3MBTL1KDM4E | |
| SCHEMBL600330 | 0.69 | ALDH1A1 (0.85) | MAPTALDH1A1LMNAL3MBTL1KDM4E | |
| SCHEMBL31276140 | 0.69 | ALDH1A1 (0.85) | MAPTALDH1A1LMNAL3MBTL1KDM4E | |
| SCHEMBL27736815 | 0.68 | MAPT (0.59) | MAPTALDH1A1LMNAL3MBTL1KDM4E | |
| SCHEMBL4190274 | 0.68 | LMNA (0.68) | MAPTALDH1A1LMNAL3MBTL1KDM4E | |
| SCHEMBL1652930 | 0.67 | ALDH1A1 (0.57) | MAPTALDH1A1LMNAL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1835908-A2 | INDOLE DERIVATIVES WITH ANTITUMOR ACTIVITY | Cell Therapeutics Europe S.R.L. (IT) | 2007-09-26 | — | — | EP | claimed |
| WO-2006066923-A2 | INDOLE DERIVATIVES WITH ANTITUMOR ACTIVITY | CELL THERAPEUTICS EUROPE S.R.L. (IT) | 2006-06-29 | — | — | WO | claimed |
| US-20090036441-A1 | Indole Derivatives With Antitumor Activity | CELL THERAPEUTICS EUROPE S.R.L. (IT) | 2009-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036441-A1 | Indole Derivatives With Antitumor Activity | IDO1, IDO2, INMT | MAPT 2732/4885ALDH1A1 467/4885LMNA 2106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.