Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1165734 | 0.80 | NOTUM (0.60) | NOTUMCYP11B2ALDH1A1HPGDNPC1 | |
| SCHEMBL1451182 | 0.79 | SMN1; SMN2 (0.42) | CA12CA1CA2CA7CA9 | |
| SCHEMBL31513387 | 0.78 | NOTUM (0.62) | CA12CA1CA2CA7CA9 | |
| SCHEMBL2188078 | 0.78 | NOTUM (0.62) | CA12CA1CA2CA7CA9 | |
| SCHEMBL7469070 | 0.77 | ESR1 (0.51) | CA12CA1CA2CA7CA9 | |
| SCHEMBL698549 | 0.76 | TSHR (0.63) | TSHRCYP11B2ALDH1A1HPGDMEN1 | |
| SCHEMBL20914962 | 0.75 | GPR119 (0.43) | NOTUMHDAC6HDAC1ESR2NPC1 | |
| SCHEMBL697671 | 0.75 | HPGD (0.68) | ALDH1A1HPGDMEN1KMT2ANPC1 | |
| SCHEMBL952264 | 0.75 | ESR1 (0.59) | NOTUMHDAC6HDAC1HDAC3ESR1 | |
| SCHEMBL8801961 | 0.74 | CA1 (0.64) | CA12CA1CA2CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1595866-B1 | Cyanopyrrolidines useful for the treatment of inter alia metabolic syndrome | SANWA KAGAKU KENKYUSHO CO (JP) | 2016-06-08 | — | — | EP | disclosed |
| US-9095575-B2 | Derivatives of 1-(substituted sulfonyl)-2-aminoimidazoline as antitumor and antiproliferative agents | ONCOARENDI THERAPEUTICS SPOLKA AKCYJNA (PL) | 2015-08-04 | — | — | US | disclosed |
| US-8981114-B2 | Derivatives of 1-(substituted sulfonyl)-2-aminoimidazoline as antitumor and antiproliferative agents | ONCOARENDI THERAPEUTICS SPOLKA AKCYJNA (PL) | 2015-03-17 | — | — | US | disclosed |
| US-20140309240-A1 | DERIVATIVES OF 1-(SUBSTITUTED SULFONYL)-2-AMINOIMIDAZOLINE AS ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | ONCOARENDI THERAPEUTICS SPOLKA AKCYJNA (PL) | 2014-10-16 | — | — | US | disclosed |
| US-20140309259-A1 | DERIVATIVES OF 1-(SUBSTITUTED SULFONYL)-2-AMINOIMIDAZOLINE AS ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | ONCOARENDI THERAPEUTICS SPOLKA AKCYJNA (PL) | 2014-10-16 | — | — | US | disclosed |
| EP-1879877-B1 | ANTIMICROBIAL AGENTS | RANBAXY LAB LTD (IN) | 2013-01-02 | — | — | EP | disclosed |
| US-8076370-B2 | Antimicrobial agents | RANBAXY LABORATORIES LIMITED (IN) | 2011-12-13 | — | — | US | disclosed |
| US-20090215764-A1 | Antimicrobial agents | RANBAXY LABORATORIES LIMITED (IN) | 2009-08-27 | — | — | US | disclosed |
| EP-1595866-A1 | COMPOUND INHIBITING DIPEPTIDYL PEPTIDASE IV | Sanwa Kagaku Kenkyusho Co., Ltd. (JP) | 2005-11-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140309259-A1 | DERIVATIVES OF 1-(SUBSTITUTED SULFONYL)-2-AMINOIMIDAZOLINE AS ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | CCNI, CCNE1, CDKN1A | CA12 3553/4885CA1 3068/4885CA2 2197/4885 |
| US-20090215764-A1 | Antimicrobial agents | TUFM, RPS17, HARS1 | CA12 2258/4885CA1 1664/4885CA2 2224/4885 |
| US-20140309240-A1 | DERIVATIVES OF 1-(SUBSTITUTED SULFONYL)-2-AMINOIMIDAZOLINE AS ANTITUMOR AND ANTIPROLIFERATIVE AGENTS | CCNI, CCNE1, CDKN1A | CA12 3553/4885CA1 3068/4885CA2 2197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.