Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.61 |
| ▸ | CA12 | O43570 | 2/20 | 0.57 |
| ▸ | CA2 | P00918 | 2/20 | 0.57 |
| ▸ | CA9 | Q16790 | 2/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA6 | P23280 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.52 |
| ▸ | FASN | P49327 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 2/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 6/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL459041 | 0.84 | PARP1 (0.57) | PARP1CA12CA2CA9CA1 | |
| Hydrochloric Acid SCHEMBL6751733 | 0.82 | PARP1 (0.55) | PARP1CA12CA2CA9CA1 | |
| SCHEMBL28079434 | 0.79 | GSK3B (0.58) | PARP1CA12CA2CA9CA1 | |
| SCHEMBL21056000 | 0.79 | CA12 (0.57) | PARP1CA12CA2CA9CA1 | |
| SCHEMBL8084159 | 0.79 | CA12 (0.57) | PARP1CA12CA2CA9CA1 | |
| SCHEMBL3850377 | 0.78 | CA12 (0.61) | PARP1CA12CA2CA9CA1 | |
| Hydrochloric Acid SCHEMBL2569130 | 0.78 | CA12 (0.55) | PARP1CA12CA2CA9CA1 | |
| SCHEMBL28583896 | 0.78 | CA12 (0.55) | PARP1CA12CA2CA9CA1 | |
| SCHEMBL28007604 | 0.78 | PARP1 (0.62) | PARP1ALDH1A1GAAMAPTMEN1 | |
| SCHEMBL2989006 | 0.78 | CA12 (0.55) | PARP1CA12CA2CA9CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130209515-A1 | ANTI-INFECTIVE AND IMMUNOMODULATORY COMPOUNDS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2013-08-15 | — | — | US | disclosed |
| US-20090215819-A1 | ANTI-INFECTIVE AND IMMUNOMODULATORY COMPOUNDS | NIH - DEITR | 2009-08-27 | — | — | US | disclosed |
| WO-2006130832-A2 | ANTI-INFECTIVE AND IMMUNOMODULATORY COMPOUNDS | THE GENERAL HOSPITAL CORPORATION (US) | 2006-12-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130209515-A1 | ANTI-INFECTIVE AND IMMUNOMODULATORY COMPOUNDS | IRF3, MAVS, MIF | PARP1 2449/4885CA12 4135/4885CA2 4152/4885 |
| US-20090215819-A1 | ANTI-INFECTIVE AND IMMUNOMODULATORY COMPOUNDS | IRF3, MAVS, MIF | PARP1 2449/4885CA12 4135/4885CA2 4152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.