Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | PMM2 | O15305 | 1/20 | 0.33 |
| ▸ | MPI | P34949 | 1/20 | 0.33 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.33 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | TYR | P14679 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5181370 | 0.70 | ESRRG (0.45) | LMNAMAPTHPGDNPC1RAB9A | |
| SCHEMBL5181374 | 0.70 | ESRRG (0.45) | LMNAMAPTHPGDNPC1RAB9A | |
| SCHEMBL10296074 | 0.69 | GAA (0.50) | TSHRPMM2MPIPHOSPHO1CYP1A2 | |
| SCHEMBL19625423 | 0.66 | NOTUM (0.40) | CYP1A2HPGDNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4118733 | 0.66 | GRIA1 (0.46) | MPIPHOSPHO1CYP1A2 | |
| SCHEMBL18125618 | 0.63 | CYP2C9 (0.52) | TSHRAMY1APKMCYP1A2LMNA | |
| SCHEMBL9588255 | 0.62 | MGLL (0.65) | PKMLMNAALDH1A1TDP1NPSR1 | |
| SCHEMBL7016863 | 0.62 | CYP2A6 (0.50) | LMNAALDH1A1MAPTTDP1BLM | |
| SCHEMBL270275 | 0.62 | MAPT (0.58) | TSHRCYP1A2LMNAALDH1A1MAPT | |
| SCHEMBL424728 | 0.62 | TSHR (0.73) | TSHRCYP1A2LMNATYRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090018183-A1 | N-phenylpyrrole guanidine derivatives as melanocortin receptor ligands | ACTION PHARMA A/S (DK) | 2009-01-15 | — | — | US | claimed |
| US-7442807-B2 | N-phenylpyrrole guanidine derivatives as melanocortin receptor ligands | ACTION PHARMA A/S (DK) | 2008-10-28 | — | — | US | claimed |
| US-20090018183-A1 | N-phenylpyrrole guanidine derivatives as melanocortin receptor ligands | ACTION PHARMA A/S (DK) | 2009-01-15 | — | — | US | disclosed |
| US-7442807-B2 | N-phenylpyrrole guanidine derivatives as melanocortin receptor ligands | ACTION PHARMA A/S (DK) | 2008-10-28 | — | — | US | disclosed |
| US-7186748-B2 | N-phenylpyrrole guanidine derivatives as melanocortin receptor ligands | ACTION PHARMA A/S (DK) | 2007-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090018183-A1 | N-phenylpyrrole guanidine derivatives as melanocortin receptor ligands | MC1R, MC5R, MC3R | TSHR 32/4885PMM2 4600/4885MPI 4807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.