SCHEMBL419154

SCHEMBL419154

Nc1ccc(S(=O)(=O)C(N)C(N)C(=O)O)c2ccccc12

nearest known ligand 0.42

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TTR P02766 1/20 0.42
SLC1A3 P43003 7/20 0.41
SLC1A2 P43004 7/20 0.41
SLC1A1 P43005 7/20 0.41
KYNU Q16719 2/20 0.40
NSD2 O96028 4/20 0.38
HDAC3 O15379 1/20 0.37
IDO1 P14902 1/20 0.37
EP300 Q09472 1/20 0.37
KAT2B Q92831 1/20 0.37
KAT8 Q9H7Z6 1/20 0.37
NCOR2 Q9Y618 1/20 0.37
LDHA P00338 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28046230 0.84 TTR (0.45) TTRSLC1A3SLC1A2SLC1A1KYNU
SCHEMBL8584521 0.82 NSD2 (0.40) TTRSLC1A3SLC1A2SLC1A1NSD2
SCHEMBL21955661 0.79 KYNU (0.36) TTRSLC1A3SLC1A2SLC1A1KYNU
SCHEMBL214991 0.78 CA2 (0.57) NSD2
SCHEMBL10964110 0.77 KYNU (0.49) TTRSLC1A3SLC1A2SLC1A1KYNU
SCHEMBL10964802 0.77 KYNU (0.49) TTRSLC1A3SLC1A2SLC1A1KYNU
SCHEMBL10765755 0.77 TTR (0.41) TTRKYNUNSD2HDAC3IDO1
SCHEMBL28639928 0.77 CA12 (0.41) TTRKYNUNSD2HDAC3IDO1
SCHEMBL10965364 0.76 KYNU (0.48) TTRSLC1A3SLC1A2SLC1A1KYNU
SCHEMBL10966276 0.76 KYNU (0.48) TTRSLC1A3SLC1A2SLC1A1KYNU

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11845807-B2 Method and carrier complexes for delivering molecules to cells CORNELL RESEARCH FOUNDATION, INC. (US) 2023-12-19 US disclosed
US-20230293624-A1 METHODS FOR PREVENTING OR TREATING MITOCHONDRIAL PERMEABILITY TRANSITION CORNELL RESEARCH FOUNDATION, INC. (US) 2023-09-21 US disclosed
US-20230149501-A1 METHODS FOR REDUCING OXIDATIVE DAMAGE CORNELL RESEARCH FOUNDATION, INC. (US) 2023-05-18 US disclosed
US-11180574-B2 Method and carrier complexes for delivering molecules to cells CORNELL RESEARCH FOUNDATION INC. (US) 2021-11-23 US disclosed
EP-3842055-A1 USES OF AROMATIC-CATIONIC PEPTIDE Cornell Research Foundation, Inc. (US) 2021-06-30 EP disclosed
US-20210015887-A1 METHODS FOR REDUCING OXIDATIVE DAMAGE CORNELL RESEARCH FOUNDATION, INC. (US) 2021-01-21 US disclosed
US-20200299415-A1 METHOD AND CARRIER COMPLEXES FOR DELIVERING MOLECULES TO CELLS CORNELL RESEARCH FOUNDATION, INC. (US) 2020-09-24 US disclosed
EP-3381515-B1 CARRIER COMPLEXES FOR DELIVERING MOLECULES TO CELLS CORNELL RES FOUNDATION INC (US) 2020-07-08 EP disclosed
EP-3659618-A1 USES OF AROMATIC-CATIONIC PEPTIDE Cornell Research Foundation, Inc. (US) 2020-06-03 EP disclosed
US-10584182-B2 Method and carrier complexes for delivering molecules to cells CORNELL RESEARCH FOUNDATION, INC. (US) 2020-03-10 US disclosed
US-20100204448-A1 METHOD AND CARRIER COMPLEXES FOR DELIVERING MOLECULES TO CELLS CORNELL RESEARCH FOUNDATION, INC. 2010-08-12 US disclosed
US-20100190718-A1 METHODS FOR PREVENTING OR TREATING MITOCHONDRIAL PERMEABILITY TRANSITION NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR 2010-07-29 US disclosed
US-7718620-B2 Methods for preventing or treating ischemia-reperfusion injury of the kidney CORNELL RESEARCH FOUNDATION, INC. (US) 2010-05-18 US disclosed
US-7704954-B2 Small peptides that are energy-independent, non-endocytotic; nontoxic, peptidase resistant CORNELL RESEARCH FOUNDATION, INC. (US) 2010-04-27 US disclosed
US-7576061-B2 Methods for preventing mitochondrial permeability transition CORNELL RESEARCH FOUNDATION, INC. (US) 2009-08-18 US disclosed
US-7550439-B2 administering aromatic cationic peptide for specifically target mitochondria; ischemia is due to stroke, sepsis, inflammatory process, arthritis, diabetes, liver disorders, viral infection, to a removed organ CORNELL RESEARCH FOUNDATION, INC. (US) 2009-06-23 US disclosed
US-20070027087-A1 METHODS FOR PREVENTING MITOCHONDRIAL PERMEABILITY TRANSITION NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2007-02-01 US disclosed
US-20060084606-A1 administering aromatic cationic peptide for specifically target mitochondria; ischemia is due to stroke, sepsis, inflammatory process, arthritis, diabetes, liver disorders, viral infection, to a removed organ CORNELL RESEARCH FOUNDATION, INC. 2006-04-20 US disclosed
US-20050158373-A1 Small peptides that are energy-independent, non-endocytotic; nontoxic, peptidase resistant NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2005-07-21 US disclosed
US-20040248808-A1 Methods for preventing mitochondrial permeability transition PUBLIC HEALTH SERVICE/NATIONAL INSTITUTES OF HEALTH (NIH) 2004-12-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100204448-A1 METHOD AND CARRIER COMPLEXES FOR DELIVERING MOLECULES TO CELLS IAPP, CD47, ANXA6 TTR 294/4885SLC1A3 622/4885SLC1A2 564/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.