SCHEMBL214991

SCHEMBL214991

CN(C)c1cccc2c(S(=O)(=O)C(N)C(N)C(=O)O)cccc12

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA2 P00918 1/20 0.57
F2 P00734 3/20 0.53
PRSS1 P07477 3/20 0.53
PRSS2 P07478 3/20 0.53
PRSS3 P35030 3/20 0.53
CYP1A2 P05177 1/20 0.49
CYP2C19 P33261 1/20 0.49
HTT P42858 1/20 0.49
HIF1A Q16665 1/20 0.49
TDP1 Q9NUW8 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
KMT2A Q03164 1/20 0.47
ATM Q13315 1/20 0.47
HDAC4 P56524 1/20 0.46
HDAC10 Q969S8 1/20 0.46
HDAC6 Q9UBN7 1/20 0.46
HDAC5 Q9UQL6 1/20 0.46
EDNRA P25101 3/20 0.45
KDM4E B2RXH2 1/20 0.42
NSD2 O96028 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28046229 0.87 CA2 (0.59) CA2F2PRSS1PRSS2PRSS3
SCHEMBL8490327 0.82 CA2 (0.47) CA2F2PRSS1PRSS2PRSS3
SCHEMBL21955660 0.82 CA2 (0.47) CA2F2PRSS1PRSS2PRSS3
SCHEMBL21955659 0.82 CA2 (0.47) CA2F2PRSS1PRSS2PRSS3
SCHEMBL27405064 0.82 CA2 (0.44) CA2F2PRSS1PRSS2PRSS3
SCHEMBL27495668 0.80 CA2 (0.64) CA2F2PRSS1PRSS2PRSS3
SCHEMBL5706282 0.79 CA2 (0.52) CA2F2PRSS1PRSS2PRSS3
SCHEMBL3765136 0.79 CA2 (0.49) CA2F2PRSS1PRSS2PRSS3
SCHEMBL28751226 0.78 F2 (0.56) CA2F2PRSS1PRSS2PRSS3
SCHEMBL419154 0.78 TTR (0.42) NSD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 384 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140378396-A1 AROMATIC-CATIONIC PEPTIDES AND USES OF SAME STEALTH BIOTHERAPEUTICS CORP (MC) 2014-12-25 US claimed
EP-4711005-A2 METHODS FOR REDUCING RISKS ASSOCIATED WITH HEART FAILURE AND FACTORS ASSOCIATED THEREWITH Stealth BioTherapeutics Inc. (US) 2026-03-18 EP disclosed
US-20260062752-A1 METHODS AND COMPOSITIONS FOR DETECTING AND DIAGNOSING DISEASES AND CONDITIONS STEALTH BIOTHERAPEUTICS INC. (US) 2026-03-05 US disclosed
US-20260061023-A1 METHODS AND COMPOSITIONS FOR THE PREVENTION OR TREATMENT OF BARTH SYNDROME STEALTH BIOTHERAPEUTICS INC. (US) 2026-03-05 US disclosed
US-20250319152-A1 METHODS FOR THE PREVENTION OR TREATMENT OF LEFT VENTRICLE REMODELING STEALTH BIOTHERAPEUTICS INC. (US) 2025-10-16 US disclosed
US-20250276116-A1 METHODS OF MITIGATING MYOCARDIAL DAMAGE DUE TO EXTRACORPOREAL MEMBRANE OXYGENATION TUFTS MEDICAL CENTER, INC. 2025-09-04 US disclosed
US-20250263433-A1 METHODS FOR REDUCING CD36 EXPRESSION CORNELL RESEARCH FOUNDATION, INC. (US) 2025-08-21 US disclosed
US-20250262269-A1 METHODS FOR PERFORMING A CORONARY ARTERY BYPASS GRAFT PROCEDURE STEALTH BIOTHERAPEUTICS INC. (US) 2025-08-21 US disclosed
US-20250255929-A1 METHODS FOR REDUCING RISKS ASSOCIATED WITH HEART FAILURE AND FACTORS ASSOCIATED THEREWITH STEALTH BIOTHERAPEUTICS INC. (US) 2025-08-14 US disclosed
EP-4596049-A2 PEPTIDE FOR USE IN PREVENTING OR TREATING MACULAR DEGENERATION Stealth BioTherapeutics Inc. (US) 2025-08-06 EP disclosed
US-20070027087-A1 METHODS FOR PREVENTING MITOCHONDRIAL PERMEABILITY TRANSITION NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2007-02-01 US disclosed
US-20070015711-A1 Administering aromatic cationic peptide for targeted mitochondria; antiischemic, -inflammatory, -arthritic, -diabetic agents, liver disorders, stroke; sepsis; viricides; organ removal; neurogenerative diseases; Parkingson's,Alzheimer's, Huntington's diseases; amyotrophic lateral sclerosis CORNELL RESEARCH FOUNDATION, INC. 2007-01-18 US disclosed
EP-1722807-A2 METHODS FOR REDUCING OXIDATIVE DAMAGE Cornell Research Foundation Inc. (US) 2006-11-22 EP disclosed
US-20060084606-A1 administering aromatic cationic peptide for specifically target mitochondria; ischemia is due to stroke, sepsis, inflammatory process, arthritis, diabetes, liver disorders, viral infection, to a removed organ CORNELL RESEARCH FOUNDATION, INC. 2006-04-20 US disclosed
EP-1625149-A2 METHOD AND CARRIER COMPLEXES FOR DELIVERING MOLECULES TO CELLS CORNELL RESEARCH FOUNDATION, INC. (US) 2006-02-15 EP disclosed
EP-1599216-A2 METHODS FOR PREVENTING MITOCHONDRIAL PERMEABILITY TRANSITION CORNELL RESEARCH FOUNDATION, INC. (US) 2005-11-30 EP disclosed
WO-2005072295-A2 METHODS FOR REDUCING OXIDATIVE DAMAGE CORNELL RESEARCH FOUNDATION, INC. (US) 2005-08-11 WO disclosed
US-20050158373-A1 Small peptides that are energy-independent, non-endocytotic; nontoxic, peptidase resistant NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2005-07-21 US disclosed
WO-2005001023-A2 METHOD AND CARRIER COMPLEXES FOR DELIVERING MOLECULES TO CELLS CORNELL RESEARCH FOUNDATION, INC. (US) 2005-01-06 WO disclosed
WO-2004070054-A2 METHODS FOR PREVENTING MITOCHONDRIAL PERMEABILITY TRANSITION CORNELL RESEARCH FOUNDATION, INC. (US) 2004-08-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140378396-A1 AROMATIC-CATIONIC PEPTIDES AND USES OF SAME PDF, AIFM1, PITRM1 CA2 2079/4885F2 1845/4885PRSS1 1674/4885
US-20260061023-A1 METHODS AND COMPOSITIONS FOR THE PREVENTION OR TREATMENT OF BARTH SYNDROME ARG2, ARGLU1, BCAT1 CA2 3372/4885F2 1609/4885PRSS1 637/4885
US-20250255929-A1 METHODS FOR REDUCING RISKS ASSOCIATED WITH HEART FAILURE AND FACTORS ASSOCIATED THEREWITH TNNI3, TNNT2, FABP3 CA2 547/4885F2 2783/4885PRSS1 1946/4885
US-20250319152-A1 METHODS FOR THE PREVENTION OR TREATMENT OF LEFT VENTRICLE REMODELING ARG2, TNNT2, MYLK2 CA2 1016/4885F2 3525/4885PRSS1 1659/4885
US-20260062752-A1 METHODS AND COMPOSITIONS FOR DETECTING AND DIAGNOSING DISEASES AND CONDITIONS ARG2, MTPN, TNNT2 CA2 2610/4885F2 2027/4885PRSS1 1254/4885
US-20250262269-A1 METHODS FOR PERFORMING A CORONARY ARTERY BYPASS GRAFT PROCEDURE RNPEP, TNNI3, BDKRB1 CA2 1498/4885F2 1787/4885PRSS1 162/4885
US-20250276116-A1 METHODS OF MITIGATING MYOCARDIAL DAMAGE DUE TO EXTRACORPOREAL MEMBRANE OXYGENATION TNNI3, TNNT2, MB CA2 215/4885F2 2144/4885PRSS1 2895/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.