Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.38 |
| ▸ | SCN1A | P35498 | 3/20 | 0.38 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.38 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28622173 | 0.77 | ALDH1A1 (0.46) | CYP2C19LMNAALDH1A1TSHRCYP3A4 | |
| SCHEMBL39931 | 0.74 | MAPT (0.48) | ALDH1A1CYP3A4KDM4ENPSR1POLB | |
| SCHEMBL1529808 | 0.73 | HTR1D (0.40) | ALDH1A1KDM4ESLC6A3L3MBTL1OPRK1 | |
| SCHEMBL40517 | 0.73 | HRH1 (0.42) | TSHRCHRM2SLC6A2SLC6A4SCN1A | |
| SCHEMBL3799389 | 0.73 | SMN1; SMN2 (0.47) | LMNAALDH1A1TSHRKDM4ERAB9A | |
| SCHEMBL3799393 | 0.73 | SMN1; SMN2 (0.47) | LMNAALDH1A1TSHRKDM4ERAB9A | |
| SCHEMBL3717619 | 0.72 | LMNA (0.40) | CYP2C19LMNAALDH1A1TSHRCYP3A4 | |
| SCHEMBL635767 | 0.72 | CYP2C19 (0.39) | CYP2C19LMNAALDH1A1TSHRCYP3A4 | |
| SCHEMBL43167 | 0.72 | CTNNB1 (0.47) | CYP2C19LMNAALDH1A1CYP1A2POLB | |
| Hydrochloric Acid SCHEMBL42821 | 0.72 | CXCR4 (0.41) | LMNAALDH1A1TSHRCHRM2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120028990-A1 | 3 ARYL OR HETEROARYL-SUBSTITUTED INDOLE DERIVATIVE | MSD K.K | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120028990-A1 | 3 ARYL OR HETEROARYL-SUBSTITUTED INDOLE DERIVATIVE | IDO1, TPH1, AHR | CYP2C19 381/4885LMNA 1992/4885ALDH1A1 2066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.