Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3238217 | 0.89 | ALDH1A1 (0.43) | LMNACYP1A2AGTR1ALDH1A1HSP90AB1 | |
| SCHEMBL22320938 | 0.84 | KMT2A (0.38) | LMNACYP1A2AGTR1ALDH1A1HSP90AB1 | |
| SCHEMBL30513670 | 0.84 | KMT2A (0.38) | LMNACYP1A2ALDH1A1ADRB2ADRB1 | |
| SCHEMBL2821675 | 0.84 | KMT2A (0.38) | LMNACYP1A2ALDH1A1ADRB2ADRB1 | |
| SCHEMBL4300671 | 0.82 | KIF11 (0.42) | LMNAHSP90AB1HTTSMN1; SMN2NR1H2 | |
| SCHEMBL9068000 | 0.81 | AGTR1 (0.39) | LMNACYP1A2AGTR1ALDH1A1L3MBTL1 | |
| Tetraethylene Glycol SCHEMBL2385287 | 0.78 | ALDH1A1 (0.39) | LMNAALDH1A1L3MBTL1HTTSMN1; SMN2 | |
| SCHEMBL8734430 | 0.77 | NR3C2 (0.37) | LMNACYP1A2AGTR1ALDH1A1HTT | |
| SCHEMBL18704105 | 0.76 | KIF11 (0.38) | LMNAALDH1A1L3MBTL1HTTNR3C2 | |
| SCHEMBL9559236 | 0.76 | HTT (0.38) | LMNACYP1A2AGTR1ALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824541-B1 | NUCLEIC ACID LIGAND COMPLEXES | GILEAD SCIENCES INC (US) | 2009-12-16 | — | — | EP | disclosed |
| US-6147204-A | COMPLEX FOR TARGETING THERAPEUTIC OR DIAGNOSTIC AGENTS TO PREFERENTIAL BIOLOGICAL TARGET | NEXSTAR PHARMACEUTICALS, INC. (US) | 2000-11-14 | — | — | US | disclosed |