Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 17/20 | 0.53 |
| ▸ | PDE4A | P27815 | 2/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4278555 | 0.88 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL23825806 | 0.87 | RBP4 (0.41) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL1056543 | 0.86 | PDE4B (0.54) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL17844321 | 0.85 | NOX1 (0.49) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL21473561 | 0.83 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL30017688 | 0.83 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL2090601 | 0.82 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL28033753 | 0.82 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DMAPT | |
| SCHEMBL631819 | 0.82 | DRD2 (0.52) | MAPT | |
| SCHEMBL21473562 | 0.81 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1648455-A4 | ANAPLASTIC LYMPHOMA KINASE MODULATORS AND METHODS OF USE | EXELIXIS INC (US) | 2009-03-04 | — | — | EP | disclosed |
| EP-1648455-A2 | ANAPLASTIC LYMPHOMA KINASE MODULATORS AND METHODS OF USE | Exelixis, Inc. (US) | 2006-04-26 | — | — | EP | disclosed |
| WO-2005009389-A2 | ANAPLASTIC LYMPHOMA KINASE MODULATORS AND METHODS OF USE | EXELIXIS, INC. (US) | 2005-02-03 | — | — | WO | disclosed |