Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 5/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.33 |
| ▸ | RET | P07949 | 3/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.33 |
| ▸ | FLT1 | P17948 | 2/20 | 0.33 |
| ▸ | LTK | P29376 | 2/20 | 0.33 |
| ▸ | GRK5 | P34947 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.33 |
| ▸ | CDK8 | P49336 | 2/20 | 0.33 |
| ▸ | CDK7 | P50613 | 2/20 | 0.33 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.33 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30170812 | 0.98 | DYRK1A (0.34) | DYRK1ALIMK1LRRK2RETCHEK1 | |
| SCHEMBL4987970 | 0.86 | CD44 (0.38) | DYRK1ALIMK1LRRK2RETCHEK1 | |
| SCHEMBL130588 | 0.86 | CD44 (0.34) | DYRK1ALIMK1LRRK2RETCHEK1 | |
| SCHEMBL29377698 | 0.86 | CD44 (0.34) | DYRK1ALIMK1LRRK2RETCHEK1 | |
| SCHEMBL361602 | 0.77 | LIMK1 (0.46) | DYRK1ALIMK1 | |
| SCHEMBL9433906 | 0.77 | LIMK1 (0.46) | DYRK1ALIMK1PI4KAPI4K2BPI4K2A | |
| SCHEMBL1013730 | 0.76 | HTR2C (0.38) | HTR2CHTR2AHTR2B | |
| SCHEMBL4198092 | 0.76 | ADCY6 (0.34) | HTR2CHTR2AHTR2B | |
| SCHEMBL4339569 | 0.76 | HTR2C (0.32) | HTR2CHTR2AHTR2B | |
| SCHEMBL31065827 | 0.76 | PNMT (0.34) | DYRK1ALIMK1LRRK2RETCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2024368-A2 | 6,7,8,9-TETRAHYDRO-5H-PYRIMIDO[4,5-D]AZEPIN-4-YL]-AMINE DERIVATIVES AS MODULATORS OF TRPV1 FOR THE TREATMENT OF PAIN | Janssen Pharmaceutica, N.V. (BE) | 2009-02-18 | — | — | EP | claimed |
| WO-2007109355-A2 | 6,7,8, 9 -TETRAHYDRO- 5H- PYRIMIDO [4, 5-D] AZEPIN-4-YL] -AMINE DERIVATIVES AS MODULATORS OF TRPVL FOR THE TREATMENT OF PAIN | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-09-27 | — | — | WO | claimed |
| EP-4110778-A1 | PYRIDOPYRIMIDINE DERIVATIVES USEFUL IN MODULATION OF AHR SIGNALLING | JAGUAHR THERAPEUTICS PTE LTD (SG) | 2023-01-04 | — | — | EP | disclosed |