SCHEMBL4196237

SCHEMBL4196237

Nc1cccc(-c2cccc(N)c2Cl)c1Cl

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.50
L3MBTL1 Q9Y468 2/20 0.50
TSHR P16473 4/20 0.46
NR4A2 P43354 1/20 0.44
CYP3A4 P08684 4/20 0.43
HSD17B10 Q99714 3/20 0.43
TDP1 Q9NUW8 2/20 0.43
HPGD P15428 2/20 0.43
ALOX15 P16050 1/20 0.42
CASP1 P29466 1/20 0.42
CASP7 P55210 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
PIK3CA P42336 1/20 0.41
MAPT P10636 2/20 0.41
KMT2A Q03164 2/20 0.41
MEN1 O00255 1/20 0.41
NPC1 O15118 1/20 0.41
POLB P06746 1/20 0.41
THRB P10828 1/20 0.41
APEX1 P27695 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31607601 1.00 ALDH1A1 (0.50) ALDH1A1L3MBTL1TSHRNR4A2CYP3A4
SCHEMBL29779254 0.86 ALDH1A1 (0.56) ALDH1A1L3MBTL1TSHRNR4A2CYP3A4
SCHEMBL23200225 0.86 ALDH1A1 (0.39) ALDH1A1L3MBTL1TSHRNR4A2CYP3A4
SCHEMBL20293728 0.86 ALDH1A1 (0.56) ALDH1A1L3MBTL1TSHRNR4A2CYP3A4
SCHEMBL22675246 0.86 ALDH1A1 (0.39) ALDH1A1L3MBTL1TSHRNR4A2CYP3A4
SCHEMBL1670544 0.84
SCHEMBL30989195 0.84 ALDH1A1 (0.42) ALDH1A1L3MBTL1TSHRNR4A2CYP3A4
SCHEMBL21647188 0.83 ALDH1A1 (0.62) ALDH1A1L3MBTL1TSHRCYP3A4HSD17B10
SCHEMBL30508983 0.83 ALDH1A1 (0.62) ALDH1A1L3MBTL1TSHRCYP3A4HSD17B10
SCHEMBL31607633 0.81 PLA2G7 (0.49) ALDH1A1L3MBTL1TSHRNR4A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260015454-A1 HIGH PERFORMANCE, AMBIENT CURE POLYURETHANES COMPRISING POLYCAPROLACTONE POLYOLS INGEVITY UK LTD (GB) 2026-01-15 US claimed
EP-4594381-A1 NOVEL POLYURETHANE OR POLYURETHANE-UREA COMPOSITION WITH ENHANCED LOW TEMPERATURE PERFORMANCE Ingevity UK Ltd (GB) 2025-08-06 EP claimed
US-20250243313-A1 POLYCAPROLACTONE POLYOLS, ELASTOMERS, AND METHODS OF MAKING AND USING THE SAME INGEVITY UK LTD (GB) 2025-07-31 US claimed
US-20250230274-A1 POLYCAPROLACTONE POLYOLS, POLYURETHANE DISPERSIONS, AND METHODS OF MAKING AND USING THE SAME INGEVITY UK LTD (GB) 2025-07-17 US claimed
WO-2025149744-A1 POLYCAPROLACTONE POLYOLS, POLYURETHANE DISPERSIONS, AND METHODS OF MAKING AND USING THE SAME INGEVITY UK LTD (GB) 2025-07-17 WO claimed
CN-120092033-A Novel polyurethane or polyurethane-urea compositions with enhanced low temperature properties 英格维蒂英国有限公司 2025-06-03 CN claimed
US-20240110002-A1 NOVEL POLYURETHANE OR POLYURETHANE-UREA COMPOSITION WITH ENHANCED LOW TEMPERATURE PERFORMANCE INGEVITY UK LTD (GB) 2024-04-04 US claimed
WO-2024068129-A1 NOVEL POLYURETHANE OR POLYURETHANE-UREA COMPOSITION WITH ENHANCED LOW TEMPERATURE PERFORMANCE INGEVITY UK LTD. (GB) 2024-04-04 WO claimed
CN-110591047-A Degradable polyether polyurethane and preparation method thereof 华南理工大学 2019-12-20 CN claimed
US-20260015454-A1 HIGH PERFORMANCE, AMBIENT CURE POLYURETHANES COMPRISING POLYCAPROLACTONE POLYOLS INGEVITY UK LTD (GB) 2026-01-15 US disclosed
EP-4594381-A1 NOVEL POLYURETHANE OR POLYURETHANE-UREA COMPOSITION WITH ENHANCED LOW TEMPERATURE PERFORMANCE Ingevity UK Ltd (GB) 2025-08-06 EP disclosed
US-20250243313-A1 POLYCAPROLACTONE POLYOLS, ELASTOMERS, AND METHODS OF MAKING AND USING THE SAME INGEVITY UK LTD (GB) 2025-07-31 US disclosed
US-20250230274-A1 POLYCAPROLACTONE POLYOLS, POLYURETHANE DISPERSIONS, AND METHODS OF MAKING AND USING THE SAME INGEVITY UK LTD (GB) 2025-07-17 US disclosed
WO-2025149744-A1 POLYCAPROLACTONE POLYOLS, POLYURETHANE DISPERSIONS, AND METHODS OF MAKING AND USING THE SAME INGEVITY UK LTD (GB) 2025-07-17 WO disclosed
US-20210139511-A1 SALTS AND CRYSTALLINE FORMS OF A PD-1/PD-L1 INHIBITOR INCYTE CORPORATION 2021-05-13 US disclosed
CN-110591047-A Degradable polyether polyurethane and preparation method thereof 华南理工大学 2019-12-20 CN disclosed
US-8227041-B2 Self-assembling block copolymer film UNIVERSITY OF SHEFFIELD (GB) 2012-07-24 US disclosed
US-20090041995-A1 Self-Assembling Block Copolymer Film UNIVERSITY OF SHEFFIELD (GB) 2009-02-12 US disclosed
EP-1866673-A1 SELF-ASSEMBLING BLOCK COPOLYMER FILM University of Sheffield (GB) 2007-12-19 EP disclosed
WO-2006103462-A1 SELF-ASSEMBLING BLOCK COPOLYMER FILM UNIVERSITY OF SHEFFIELD (GB) 2006-10-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260015454-A1 HIGH PERFORMANCE, AMBIENT CURE POLYURETHANES COMPRISING POLYCAPROLACTONE POLYOLS PUF60, MORF4L1, C9 ALDH1A1 538/4885L3MBTL1 647/4885TSHR 4502/4885
US-20210139511-A1 SALTS AND CRYSTALLINE FORMS OF A PD-1/PD-L1 INHIBITOR CD274, PDCD1, PDCD1LG2 ALDH1A1 295/4885L3MBTL1 664/4885TSHR 1358/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.