Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.94 |
| ▸ | IDO1 | P14902 | 1/20 | 0.55 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.52 |
| ▸ | RECQL | P46063 | 2/20 | 0.52 |
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | CASP1 | P29466 | 1/20 | 0.52 |
| ▸ | SNCA | P37840 | 1/20 | 0.52 |
| ▸ | NQO2 | P16083 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | PLAU | P00749 | 1/20 | 0.52 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.52 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1-Naphthol SCHEMBL27527869 | 1.00 | CYP1A2 (0.94) | CYP1A2IDO1PTPN22HSD17B10TDP1 | |
| 1-Naphthol SCHEMBL10486461 | 0.97 | CYP1A2 (1.00) | CYP1A2IDO1PTPN22HSD17B10TDP1 | |
| 1-Naphthol SCHEMBL3416 | 0.97 | CYP1A2 (1.00) | CYP1A2IDO1PTPN22HSD17B10TDP1 | |
| 1-Naphthol SCHEMBL29767730 | 0.97 | CYP1A2 (1.00) | CYP1A2IDO1PTPN22HSD17B10TDP1 | |
| 1-Naphthol SCHEMBL273260 | 0.97 | CYP1A2 (1.00) | CYP1A2IDO1PTPN22HSD17B10TDP1 | |
| 1-Naphthol SCHEMBL11247168 | 0.94 | CYP1A2 (0.94) | CYP1A2IDO1PTPN22HSD17B10TDP1 | |
| 1-Naphthol SCHEMBL3924043 | 0.94 | CYP1A2 (0.94) | CYP1A2IDO1PTPN22HSD17B10TDP1 | |
| 1-Naphthol SCHEMBL11295882 | 0.94 | CYP1A2 (0.94) | CYP1A2IDO1PTPN22HSD17B10TDP1 | |
| 1-Naphthol SCHEMBL21490911 | 0.94 | CYP1A2 (0.94) | CYP1A2IDO1PTPN22HSD17B10TDP1 | |
| 1-Naphthol SCHEMBL9850309 | 0.94 | CYP1A2 (0.94) | CYP1A2IDO1PTPN22HSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1068876-C | Process for preparing chiral succinic acid derivatives | HOFFMANN LA ROCHE (CH) | 2001-07-25 | — | — | CN | claimed |
| CN-1177595-A | Process for preparing chiral succinic acid derivatives | HOFFMANN LA ROCHE (CH) | 1998-04-01 | — | — | CN | claimed |
| CN-104788462-B | Chiral polysubstituted 4-hydroxychroman compound, and preparation method and application thereof | 中国科学院化学研究所 | 2017-02-08 | — | — | CN | disclosed |
| US-20090036441-A1 | Indole Derivatives With Antitumor Activity | CELL THERAPEUTICS EUROPE S.R.L. (IT) | 2009-02-05 | — | — | US | disclosed |
| CN-101083983-A | Indole derivatives with antitumor activity | CELL THERAPEUTICS EUROPE SRL (IT) | 2007-12-05 | — | — | CN | disclosed |
| CN-1308066-A | Preparation of chiral succinic acid derivative | HOFFMANN LA ROCHE (CH) | 2001-08-15 | — | — | CN | disclosed |
| CN-1068876-C | Process for preparing chiral succinic acid derivatives | HOFFMANN LA ROCHE (CH) | 2001-07-25 | — | — | CN | disclosed |
| CN-1177595-A | Process for preparing chiral succinic acid derivatives | HOFFMANN LA ROCHE (CH) | 1998-04-01 | — | — | CN | disclosed |
| CN-1066075-A | PROCESS FOR PREPARING POLYOLEFINS | NIPPON OIL CO LTD (JP) | 1992-11-11 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090036441-A1 | Indole Derivatives With Antitumor Activity | IDO1, IDO2, INMT | CYP1A2 259/4885IDO1 1/4885PTPN22 4535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.