Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
| ▸ | CES2 | O00748 | 2/20 | 0.32 |
| ▸ | CES1 | P23141 | 2/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | KCNN4 | O15554 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2588967 | 0.82 | ALDH1A1 (0.41) | PARP1HPGDKDM4EPOLBALDH1A1 | |
| SCHEMBL14053273 | 0.76 | CYP1A2 (0.42) | KDM4E | |
| SCHEMBL3265387 | 0.74 | CES2 (0.39) | KDM4EPOLBCES2CES1ALDH1A1 | |
| SCHEMBL14053331 | 0.72 | IRAK4 (0.42) | HPGDPOLBALDH1A1 | |
| SCHEMBL653173 | 0.71 | FSCN1 (0.51) | PARP1HPGDKDM4EALDH1A1 | |
| Carbamic Acid SCHEMBL11787925 | 0.70 | TSHR (0.48) | PARP1GRM2HPGDKEAP1 | |
| SCHEMBL320721 | 0.70 | KCNN4 (0.42) | CES2CES1KCNN4ALDH1A1 | |
| SCHEMBL526256 | 0.69 | TSHR (0.39) | ALDH1A1 | |
| SCHEMBL1785686 | 0.68 | ALDH1A1 (0.50) | PARP1GRM2HPGDKEAP1CES2 | |
| SCHEMBL9264543 | 0.68 | PARP1 (0.48) | PARP1CES2CES1KCNN4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026345-A1 | THIAZOLIDINONE COMPOUNDS, AND METHODS OF MAKING AND USING SAME | TARGEGEN INC. (US) | 2009-02-26 | — | — | WO | disclosed |