Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.38 |
| ▸ | PPARA | Q07869 | 5/20 | 0.38 |
| ▸ | PPARD | Q03181 | 2/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.34 |
| ▸ | APLNR | P35414 | 4/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.32 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.32 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1963085 | 0.79 | RECQL (0.39) | PPARGPPARAALDH3A1PTGDR2PTGDR | |
| SCHEMBL1959066 | 0.78 | ALDH1A1 (0.39) | PPARGPPARAALDH3A1PTGDR2PTGDR | |
| SCHEMBL4197377 | 0.72 | GRIN1 (0.39) | PTGDR2PTGDRTSHRHTR6 | |
| SCHEMBL25153267 | 0.71 | ENPP3 (0.44) | PPARGPPARAPPARDPTGDR2TSHR | |
| SCHEMBL30280436 | 0.71 | ENPP3 (0.44) | PPARGPPARAPPARDPTGDR2TSHR | |
| SCHEMBL1963563 | 0.70 | RECQL (0.36) | RECQLHTR6 | |
| SCHEMBL1960448 | 0.70 | RECQL (0.41) | ALDH3A1PTGDR2PTGDRRECQLTSHR | |
| SCHEMBL9701252 | 0.69 | CYP2C19 (0.49) | PPARGPPARAPPARDPTGDR2RECQL | |
| SCHEMBL23246934 | 0.69 | PIK3C3 (0.41) | PPARGPPARAPPARDPTGDR2RECQL | |
| SCHEMBL1962367 | 0.69 | PTGS2 (0.40) | ALDH3A1PTGDR2NOD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513103-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. Hoffmann-La Roche AG (CH) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011073117-A1 | AZAINDOLE GLUCOKINASE ACTIVATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2011-06-23 | — | — | WO | disclosed |