Guanine

Guanine

SCHEMBL4198112

Nc1nc2nc[nH]c2c(=O)[nH]1.OC[C@H]1OC[C@H](O)[C@@H]1O

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
PNP P00491 9/20 0.58
GDA Q9Y2T3 1/20 0.39
KDM4E B2RXH2 1/20 0.39
MEN1 O00255 1/20 0.39
ALDH1A1 P00352 1/20 0.39
MAPT P10636 1/20 0.39
THRB P10828 1/20 0.39
HPGD P15428 1/20 0.39
KMT2A Q03164 1/20 0.39
HSD17B10 Q99714 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Guanine SCHEMBL65307 0.83 PNP (0.62) PNPGDAKDM4EMEN1ALDH1A1
Guanine SCHEMBL28384883 0.83 PNP (0.62) PNPGDAKDM4EMEN1ALDH1A1
Guanine SCHEMBL4359248 0.83 PNP (0.62) PNPGDAKDM4EMEN1ALDH1A1
SCHEMBL4201094 0.81 PNP (0.42) PNPMEN1KMT2A
2,6-Diaminopurine SCHEMBL443468 0.81 PDPK1 (0.55) GDA
SCHEMBL15602792 0.79 PDPK1 (0.40) GDA
SCHEMBL10607653 0.78 PNP (0.39) PNPMEN1ALDH1A1HPGDKMT2A
SCHEMBL4194716 0.78 MAPT (0.55) PNPMEN1MAPTKMT2A
Adenine SCHEMBL593934 0.77 PI4KA (0.54) PNPGDAHSD17B10
Guanine SCHEMBL4197782 0.77 PNP (0.53) PNPGDAKDM4EMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5397706-A Serum-free basal and culture medium for hematopoietic and leukemia cells CORREA PAULO N (CA) 1995-03-14 US claimed
WO-1993009220-A1 CELL CULTURE MEDIUM CORREA PAULO N (CA) 1993-05-13 WO claimed
EP-0122151-B1 PRODUCTION OF PRIMARY OR SECONDARY ALCOHOL DERIVATIVES OF PHOSPHOLIPIDS BY THE ENZYMATIC TECHNIQUE MEITO SANGYO KABUSHIKI KAISHA (JP) 1989-02-15 EP claimed
US-4783402-A Production of primary or secondary alcohol derivatives of phospholipids by the enzymatic technique MEITO SANGYO KABUSHIKI KAISHA (JP) 1988-11-08 US claimed
EP-0122151-A2 Production of primary or secondary alcohol derivatives of phospholipids by the enzymatic technique MEITO SANGYO KABUSHIKI KAISHA (JP) 1984-10-17 EP claimed
EP-4417695-A2 MODIFIED CIRCULAR RNAS AND METHODS OF USE THEREOF The Board of Trustees of the Leland Stanford Junior University (US) 2024-08-21 EP disclosed
US-20220288176-A1 CIRCULAR RNA MODIFICATION AND METHODS OF USE THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY 2022-09-15 US disclosed
EP-4022069-A1 MODIFIED CIRCULAR RNAS AND METHODS OF USE THEREOF The Board of Trustees of the Leland Stanford Junior University (US) 2022-07-06 EP disclosed
WO-2021041541-A1 MODIFIED CIRCULAR RNAS AND METHODS OF USE THEREOF THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2021-03-04 WO disclosed
EP-3052102-A1 COMPOSITIONS AND METHODS FOR TREATING CANCERS Aptose Biosciences Inc. (CA) 2016-08-10 EP disclosed
WO-2015051302-A1 COMPOSITIONS AND METHODS FOR TREATING CANCERS APTOSE BIOSCIENCES INC. (CA) 2015-04-09 WO disclosed
US-7608402-B2 DNA methylation specific signal amplification LI WEIWEI 2009-10-27 US disclosed
US-20090181373-A1 DNA methylation specific signal amplification LI WEIWEI 2009-07-16 US disclosed
US-5397706-A Serum-free basal and culture medium for hematopoietic and leukemia cells CORREA PAULO N (CA) 1995-03-14 US disclosed
WO-1993009220-A1 CELL CULTURE MEDIUM CORREA PAULO N (CA) 1993-05-13 WO disclosed
US-4404368-A Lyophilized phosphorylated nucleosides ENS BIOLOGICALS INC. (CA) 1983-09-13 US disclosed
EP-0058563-A1 Lyophilized phosphorylated nucleosides ens BIO LOGICALS INC. (CA) 1982-08-25 EP disclosed