Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRPF1 | P55201 | 17/20 | 0.55 |
| ▸ | BRD9 | Q9H8M2 | 6/20 | 0.55 |
| ▸ | BRD4 | O60885 | 5/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.55 |
| ▸ | BRD1 | O95696 | 10/20 | 0.37 |
| ▸ | BRPF3 | Q9ULD4 | 5/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | BCL6 | P41182 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1450538 | 0.85 | BRPF1 (0.55) | BRPF1BRD9BRD4CA12CA9 | |
| SCHEMBL9080236 | 0.77 | MAPT (0.55) | — | |
| SCHEMBL4198042 | 0.77 | BTK (0.39) | — | |
| SCHEMBL27335443 | 0.74 | — | — | |
| Hydrochloric Acid SCHEMBL7218030 | 0.72 | BRPF1 (0.92) | BRPF1BRD9BRD4CA12CA9 | |
| SCHEMBL29967380 | 0.71 | BRPF1 (1.00) | BRPF1BRD9BRD4CA12CA9 | |
| SCHEMBL248619 | 0.71 | BRPF1 (1.00) | BRPF1BRD9BRD4CA12CA9 | |
| SCHEMBL552070 | 0.71 | PIK3CD (0.43) | BRPF1BRD4PIK3CDPIK3CAPIK3CB | |
| SCHEMBL1419488 | 0.71 | MEN1 (0.37) | — | |
| Hydrochloric Acid SCHEMBL1236989 | 0.69 | BRPF1 (0.96) | BRPF1BRD9BRD4CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623614-B1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1998-02-25 | — | — | EP | claimed |
| US-5519022-A | α, α dialkylbenzyl derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1996-05-21 | — | — | US | claimed |
| US-5478842-A | Antiinflammatory agents, antiallergens, drugs for treatment of diseases mediated by leukotrienes | ZENECA LIMITED (GB) | 1995-12-26 | — | — | US | claimed |
| EP-0462812-B1 | Pyran derivatives as inhibitors of 5-lipoxygenase | ZENECA LTD (GB) | 1995-12-06 | — | — | EP | claimed |
| EP-0462830-B1 | Cyclic ether derivatives | ZENECA LTD (GB) | 1995-10-18 | — | — | EP | claimed |
| US-5407945-A | Pyran derivatives and their use as inhibitors of 5-lipoxygenase | IMPERIAL CHEMICAL INDUSTRIES, INC. (GB) | 1995-04-18 | — | — | US | claimed |
| US-5367079-A | Lipoxygenase inhibitors; antiinflammatory agents, antiallergens | ZENECA LIMITED (GB) | 1994-11-22 | — | — | US | claimed |
| WO-1994025453-A1 | 4-ARYL-4-HYDROXY-TETRAHYDROPYRANS AND 3-ARYL-3-HYDROXY-TETRAHYDROFURANS AS 5-LIPOXYGENASE INHIBITORS | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | claimed |
| EP-0623614-A1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1994-11-09 | — | — | EP | claimed |
| EP-0420511-B1 | Heterocyclic derivatives | ICI PLC (GB) | 1994-08-17 | — | — | EP | claimed |
| EP-0570112-A1 | Cycloalkane derivatives | ZENECA LIMITED (GB) | 1993-11-18 | — | — | EP | claimed |
| US-5232930-A | Antiinflammatory antiallergen | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-03 | — | — | US | claimed |
| US-5221677-A | For treating diseases mediated by leukotrienes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-22 | — | — | US | claimed |
| US-5217978-A | Lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-08 | — | — | US | claimed |
| EP-0540165-A1 | Alkanoic acid derivatives | ZENECA LIMITED (GB) | 1993-05-05 | — | — | EP | claimed |
| EP-0505122-A1 | Alpha, alpha-dialkylbenzyl derivatives | ZENECA LIMITED (GB) | 1992-09-23 | — | — | EP | claimed |
| EP-0500205-A1 | Benzodioxole derivatives | ZENECA LIMITED (GB) | 1992-08-26 | — | — | EP | claimed |
| EP-0462830-A2 | Cyclic ether derivatives | ZENECA LIMITED (GB) | 1991-12-27 | — | — | EP | claimed |
| EP-0462812-A2 | Pyran derivatives as inhibitors of 5-lipoxygenase | ZENECA LIMITED (GB) | 1991-12-27 | — | — | EP | claimed |
| EP-0420511-A2 | Heterocyclic derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1991-04-03 | — | — | EP | claimed |