Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4198329 | 0.77 | BRPF1 (0.55) | — | |
| SCHEMBL2332129 | 0.71 | MAPT (1.00) | MAPTALDH1A1RXFP1 | |
| SCHEMBL1419488 | 0.71 | MEN1 (0.37) | MAPTALDH1A1 | |
| SCHEMBL443607 | 0.69 | PRKCI (0.44) | MAPTALDH1A1RXFP1 | |
| SCHEMBL3482998 | 0.69 | — | — | |
| SCHEMBL694594 | 0.67 | CDK4 (0.41) | — | |
| SCHEMBL975060 | 0.66 | GPR3 (0.44) | MAPTALDH1A1 | |
| SCHEMBL148060 | 0.66 | KCNH2 (0.49) | MAPTALDH1A1 | |
| SCHEMBL16720318 | 0.66 | BIRC5 (0.39) | — | |
| SCHEMBL689746 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462812-B1 | Pyran derivatives as inhibitors of 5-lipoxygenase | ZENECA LTD (GB) | 1995-12-06 | — | — | EP | claimed |
| EP-0466452-B1 | Thioxo heterocycles and their pharmaceutical use | ZENECA LTD (GB) | 1995-09-20 | — | — | EP | claimed |
| US-5240941-A | Enzyme inhibitors; antiinflammatory agents, antiallergens | ICI PHARMA (FR) | 1993-08-31 | — | — | US | claimed |
| US-5232930-A | Antiinflammatory antiallergen | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-03 | — | — | US | claimed |
| US-5217978-A | Lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-08 | — | — | US | claimed |
| EP-0500205-A1 | Benzodioxole derivatives | ZENECA LIMITED (GB) | 1992-08-26 | — | — | EP | claimed |
| EP-0466452-A2 | Thioxo heterocycles and their pharmaceutical use | ZENECA LIMITED (GB) | 1992-01-15 | — | — | EP | claimed |
| EP-0462812-A2 | Pyran derivatives as inhibitors of 5-lipoxygenase | ZENECA LIMITED (GB) | 1991-12-27 | — | — | EP | claimed |
| US-5519022-A | α, α dialkylbenzyl derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1996-05-21 | — | — | US | disclosed |
| US-5484805-A | LIPOXYGENASE INHIBITORS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1996-01-16 | — | — | US | disclosed |
| EP-0462812-B1 | Pyran derivatives as inhibitors of 5-lipoxygenase | ZENECA LTD (GB) | 1995-12-06 | — | — | EP | disclosed |
| EP-0466452-B1 | Thioxo heterocycles and their pharmaceutical use | ZENECA LTD (GB) | 1995-09-20 | — | — | EP | disclosed |
| US-5359063-A | Lipoxygenase inhibitor | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-10-25 | — | — | US | disclosed |
| US-5288742-A | Lipoxygenase inhibitor | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1994-02-22 | — | — | US | disclosed |
| US-5232930-A | Antiinflammatory antiallergen | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-08-03 | — | — | US | disclosed |
| US-5217978-A | Lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-08 | — | — | US | disclosed |
| EP-0505122-A1 | Alpha, alpha-dialkylbenzyl derivatives | ZENECA LIMITED (GB) | 1992-09-23 | — | — | EP | disclosed |
| EP-0500205-A1 | Benzodioxole derivatives | ZENECA LIMITED (GB) | 1992-08-26 | — | — | EP | disclosed |
| EP-0466452-A2 | Thioxo heterocycles and their pharmaceutical use | ZENECA LIMITED (GB) | 1992-01-15 | — | — | EP | disclosed |
| EP-0462812-A2 | Pyran derivatives as inhibitors of 5-lipoxygenase | ZENECA LIMITED (GB) | 1991-12-27 | — | — | EP | disclosed |