Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.49 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.49 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.47 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4215163 | 0.85 | NPC1 (0.54) | NPC1MAPK8ANO1RAB9AKMT2A | |
| SCHEMBL4209304 | 0.84 | POLB (0.43) | NPC1RAB9AMEN1KMT2APOLB | |
| SCHEMBL15449548 | 0.83 | ALDH1A1 (0.44) | NPC1MAPK8ANO1RAB9AMEN1 | |
| SCHEMBL4211528 | 0.83 | CYP1A2 (0.57) | NPC1MAPK8ANO1RAB9AMEN1 | |
| SCHEMBL4199348 | 0.80 | CSF1R (0.49) | ANO1POLBP2RX7 | |
| SCHEMBL4203468 | 0.79 | EPHX2 (0.54) | CACNA1GCACNA1HCACNA1IRAB9AMEN1 | |
| SCHEMBL12323598 | 0.75 | KMT2A (0.67) | NPC1MAPK8ANO1RAB9AMEN1 | |
| SCHEMBL12323599 | 0.75 | HPGD (0.62) | NPC1MAPK8RAB9AMEN1KMT2A | |
| SCHEMBL16772783 | 0.75 | NPC1 (0.56) | NPC1CACNA1GCACNA1HCACNA1IMAPK8 | |
| SCHEMBL3110192 | 0.75 | RECQL (0.54) | NPC1ANO1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160376291-A1 | IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 | JANSSEN PHARMACEUTICA NV (BE) | 2016-12-29 | — | — | US | disclosed |
| US-20160376291-A1 | IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 | JANSSEN PHARMACEUTICA NV (BE) | 2016-12-29 | — | — | US | disclosed |
| US-9440978-B2 | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 | JANSSEN PHARMACEUTICA NV (BE) | 2016-09-13 | — | — | US | disclosed |
| US-9440978-B2 | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 | JANSSEN PHARMACEUTICA NV (BE) | 2016-09-13 | — | — | US | disclosed |
| US-9440978-B2 | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 | JANSSEN PHARMACEUTICA NV (BE) | 2016-09-13 | — | — | US | disclosed |
| EP-2224929-B1 | IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 | JANSSEN PHARMACEUTICA NV (BE) | 2016-05-04 | — | — | EP | disclosed |
| EP-2224929-B1 | IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 | JANSSEN PHARMACEUTICA NV (BE) | 2016-05-04 | — | — | EP | disclosed |
| US-20140107098-A1 | IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 | JANSSEN PHARMACEUTICA NV (US) | 2014-04-17 | — | — | US | disclosed |
| US-20140107098-A1 | IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 | JANSSEN PHARMACEUTICA NV (US) | 2014-04-17 | — | — | US | disclosed |
| US-20140107098-A1 | IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 | JANSSEN PHARMACEUTICA NV (US) | 2014-04-17 | — | — | US | disclosed |
| US-20130005687-A1 | IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 | BRANSTETTER BRYAN JAMES (US) | 2013-01-03 | — | — | US | disclosed |
| US-20130005687-A1 | IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 | BRANSTETTER BRYAN JAMES (US) | 2013-01-03 | — | — | US | disclosed |
| US-20130005687-A1 | IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 | BRANSTETTER BRYAN JAMES (US) | 2013-01-03 | — | — | US | disclosed |
| US-8288397-B2 | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 | JANSSEN PHARMACEUTICA NV (BE) | 2012-10-16 | — | — | US | disclosed |
| US-8288397-B2 | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 | JANSSEN PHARMACEUTICA NV (BE) | 2012-10-16 | — | — | US | disclosed |
| US-8288397-B2 | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 | JANSSEN PHARMACEUTICA NV (BE) | 2012-10-16 | — | — | US | disclosed |
| WO-2009078999-A1 | IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-06-25 | — | — | WO | disclosed |
| US-20090156599-A1 | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-18 | — | — | US | disclosed |
| US-20090156599-A1 | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-18 | — | — | US | disclosed |
| US-20090156599-A1 | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 | JANSSEN PHARMACEUTICA NV (BE) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160376291-A1 | IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 | TRPV1, TRPA1, TRPV4 | NPC1 1191/4885CACNA1G 551/4885CACNA1H 826/4885 |
| US-20130005687-A1 | IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 | TRPV1, TRPA1, TRPV4 | NPC1 1191/4885CACNA1G 551/4885CACNA1H 826/4885 |
| US-20140107098-A1 | IMIDAZOLO-, OXAZOLO-, AND THIAZOLOPYRIMIDINE MODULATORS OF TRPV1 | TRPV1, TRPA1, TRPV4 | NPC1 1191/4885CACNA1G 551/4885CACNA1H 826/4885 |
| US-20090156599-A1 | Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of TRPV1 | TRPV1, TRPA1, TRPV4 | NPC1 1191/4885CACNA1G 551/4885CACNA1H 826/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.