Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK14 | O94921 | 14/20 | 0.47 |
| ▸ | CCNY | Q8ND76 | 12/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.41 |
| ▸ | CASK | O14936 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | MAK | P20794 | 1/20 | 0.41 |
| ▸ | CDK11B | P21127 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CCND3 | P30281 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2029686 | 0.77 | CDK14 (0.48) | CDK14CCNYLMNARAB9ACDK2 | |
| SCHEMBL17252164 | 0.77 | CDK14 (0.70) | CDK14CCNYCDK2CCNA1CASK | |
| SCHEMBL4440869 | 0.77 | TYK2 (0.58) | MAPK7KMT2A | |
| SCHEMBL13993660 | 0.75 | LMNA (0.46) | CDK14CCNYLMNARAB9ACDK2 | |
| SCHEMBL29164525 | 0.74 | TYK2 (0.63) | RAB9AMAPK7 | |
| SCHEMBL8262596 | 0.72 | CDK14 (0.43) | CDK14CCNYLMNARAB9ACDK2 | |
| SCHEMBL8261492 | 0.72 | CDK2 (0.49) | CDK14CCNYLMNARAB9AMAPT | |
| SCHEMBL4936632 | 0.72 | CDK14 (0.46) | CDK14CCNYLMNARAB9ACDK2 | |
| SCHEMBL8263999 | 0.71 | CDK14 (0.52) | CDK14CCNYLMNARAB9ACDK2 | |
| SCHEMBL8261512 | 0.70 | CDK14 (0.44) | CDK14CCNYLMNARAB9ACCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2027109-A1 | 4- (2, 6-DICHLORO-BENZOYLAMINO) -1H-PYRAZOLE-S-CARBOXYLIC ACID (1-METHANESULPH0NYL-PIPERIDIN-4-YL) -AMIDE FOR THE TREATMENT OF CANCER | Astex Therapeutics Limited (GB) | 2009-02-25 | — | — | EP | disclosed |