Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 12/20 | 0.52 |
| ▸ | CES1 | P23141 | 5/20 | 0.47 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.46 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.46 |
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.46 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.44 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20339307 | 0.99 | FAAH (0.50) | FAAHCES1SOAT2SOAT1DAGLA | |
| Hydrochloric Acid SCHEMBL19691934 | 0.81 | FAAH (0.53) | FAAHCES1SOAT2SOAT1DAGLA | |
| SCHEMBL27861997 | 0.77 | HTT (0.56) | FAAHCES1SOAT2SOAT1DAGLA | |
| SCHEMBL28341165 | 0.77 | SOAT2 (0.55) | FAAHCES1SOAT2SOAT1DAGLA | |
| SCHEMBL9602533 | 0.77 | HTT (0.56) | FAAHCES1SOAT2SOAT1DAGLA | |
| SCHEMBL25383771 | 0.76 | FAAH (0.57) | FAAHCES1SOAT2SOAT1DAGLA | |
| SCHEMBL27502912 | 0.76 | SOAT2 (0.53) | FAAHCES1SOAT2SOAT1DAGLA | |
| SCHEMBL7170901 | 0.76 | SOAT1 (0.53) | FAAHCES1SOAT2SOAT1DAGLA | |
| SCHEMBL2856074 | 0.76 | SOAT2 (0.53) | FAAHCES1SOAT2SOAT1DAGLA | |
| SCHEMBL28430631 | 0.75 | SOAT2 (0.52) | FAAHCES1SOAT2SOAT1DAGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1408932-A4 | PARTICLES WITH IMPROVED SOLUBILIZATION CAPACITY | LYOTROPIC THERAPEUTICS INC (US) | 2009-02-25 | — | — | EP | disclosed |
| EP-1408932-A1 | PARTICLES WITH IMPROVED SOLUBILIZATION CAPACITY | Lyotropic Therapeutics, LLC (US) | 2004-04-21 | — | — | EP | disclosed |
| WO-2003000236-A1 | PARTICLES WITH IMPROVED SOLUBILIZATION CAPACITY | LYOTROPIC THERAPEUTICS, INC (US) | 2003-01-03 | — | — | WO | disclosed |