Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4197849 | 0.83 | LMNA (0.43) | LMNAGAAPKML3MBTL1RYR2 | |
| SCHEMBL4191321 | 0.77 | LMNA (0.34) | LMNAGAAIKBKBALDH1A1 | |
| SCHEMBL4199003 | 0.77 | BRD4 (0.36) | LMNAL3MBTL1IKBKBALDH1A1TSHR | |
| SCHEMBL4202856 | 0.76 | CYP2D6 (0.32) | LMNAGAAPKML3MBTL1IKBKB | |
| SCHEMBL4196412 | 0.74 | CA2 (0.33) | LMNAGAAPKMNPC1 | |
| SCHEMBL4288139 | 0.74 | L3MBTL1 (0.49) | LMNAGAAPKML3MBTL1KDM4E | |
| SCHEMBL4205152 | 0.73 | LMNA (0.38) | LMNAGAAPKML3MBTL1RYR2 | |
| SCHEMBL4203149 | 0.73 | — | — | |
| SCHEMBL26140963 | 0.71 | APP (0.37) | LMNACYP2C19 | |
| SCHEMBL4207795 | 0.71 | TSHR (0.34) | GAANPC1IKBKBCYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032559-A1 | 2-HETEROCYCLOAMINO-4-IMIDAZOLYLPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2009-03-11 | — | — | EP | disclosed |
| WO-2007138268-A1 | 2-HETEROCYCLOAMINO-4-IMIDAZOLYLPYRIMIDINES AS AGENTS FOR THE INHIBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2007-12-06 | — | — | WO | disclosed |