Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPI | P09923 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.52 |
| ▸ | XIAP | P98170 | 1/20 | 0.52 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.52 |
| ▸ | KIF11 | P52732 | 4/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.44 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.44 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.44 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | KYNU | Q16719 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4199918 | 1.00 | ALPI (0.52) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL2836743 | 0.86 | ALPI (0.41) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL3930879 | 0.81 | CYP2D6 (0.46) | KIF11SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL25358402 | 0.81 | ALPI (0.48) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL31369636 | 0.81 | ALPI (0.48) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL25358407 | 0.81 | ALPI (0.48) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL2703603 | 0.80 | LTA4H (0.51) | KIF11KDM4EL3MBTL1POLBAPOBEC3A | |
| SCHEMBL2703155 | 0.80 | LTA4H (0.51) | KIF11KDM4EL3MBTL1POLBAPOBEC3A | |
| SCHEMBL542094 | 0.78 | PTGS1 (0.42) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL8113492 | 0.78 | KDM4E (0.47) | KDM4EL3MBTL1POLBAPOBEC3AAPOBEC3G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809358-B2 | Use of IκB-kinase inhibitors in pain therapy | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2014-08-19 | — | — | US | disclosed |
| US-20090069358-A1 | Use of IKappaB-Kinase Inhibitors in Pain Therapy | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-03-12 | — | — | US | disclosed |
| US-7462638-B2 | Use of IκB-kinase inhibitors in pain therapy | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-12-09 | — | — | US | disclosed |
| US-7285560-B2 | Indole derivatives or benzimidazole derivatives for modulating IκB kinase | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-10-23 | — | — | US | disclosed |
| US-20070244139-A1 | Indole Derivatives or Benzimidazole Derivatives for Modulating IkB Kinase | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-10-18 | — | — | US | disclosed |
| US-20050197353-A1 | Indole derivatives or benzimidazole derivatives for modulating IkB kinase | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-09-08 | — | — | US | disclosed |
| US-20040116494-A1 | Use of IkappaB-kinase inhibitors in pain therapy | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-06-17 | — | — | US | disclosed |
| US-6166072-A | Amino acid derivatives | ALLELIX NEUROSCIENCE, INC. (CA) | 2000-12-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070244139-A1 | Indole Derivatives or Benzimidazole Derivatives for Modulating IkB Kinase | IKBKB, IKBKG, IKBKE | ALPI 962/4885PKM 503/4885PTGS1 573/4885 |
| US-20090069358-A1 | Use of IKappaB-Kinase Inhibitors in Pain Therapy | NFKBIA, IKBKB, IKBKE | ALPI 991/4885PKM 1173/4885PTGS1 26/4885 |
| US-20050197353-A1 | Indole derivatives or benzimidazole derivatives for modulating IkB kinase | IKBKB, IKBKG, IKBKE | ALPI 962/4885PKM 503/4885PTGS1 573/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.