Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | GLS | O94925 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SCD | O00767 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3577082 | 0.80 | ALDH1A1 (0.62) | ALDH1A1NPC1RAB9ASMN1; SMN2RXFP1 | |
| SCHEMBL3583788 | 0.80 | SCD (0.74) | ALDH1A1NPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL27727895 | 0.79 | SCD (0.47) | ALDH1A1NPC1RAB9ASMN1; SMN2RXFP1 | |
| SCHEMBL3590753 | 0.79 | LMNA (0.64) | ALDH1A1NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL4202353 | 0.77 | RAB9A (0.68) | ALDH1A1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL3584201 | 0.75 | RAB9A (0.71) | ALDH1A1NPC1RAB9ASMN1; SMN2HPGD | |
| SCHEMBL3585209 | 0.75 | ALDH1A1 (0.64) | ALDH1A1NPC1RAB9ASMN1; SMN2RXFP1 | |
| SCHEMBL16481385 | 0.74 | ALDH1A1 (0.56) | ALDH1A1NPC1RAB9ASMN1; SMN2RXFP1 | |
| SCHEMBL8553614 | 0.74 | ALDH1A1 (0.47) | ALDH1A1NPC1RAB9ASMN1; SMN2RXFP1 | |
| SCHEMBL774408 | 0.74 | LCK (0.63) | NPC1RAB9ASMN1; SMN2GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029138-A1 | AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007130075-A1 | AMINOTHIAZOLE DERIVATIVES AS HUMAN STEAROYL-COA DESATURASE INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2007-11-15 | — | — | WO | disclosed |