Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 2/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15875591 | 0.77 | HSD11B1 (0.51) | HSD11B1P2RX7IDO1CDC7ALDH1A1 | |
| SCHEMBL1646429 | 0.75 | P2RX7 (0.60) | HSD11B1P2RX7IDO1CDC7ALDH1A1 | |
| SCHEMBL2895624 | 0.75 | CDC7 (0.54) | HSD11B1P2RX7IDO1CDC7ALDH1A1 | |
| SCHEMBL27676262 | 0.74 | P2RX7 (0.46) | P2RX7IDO1ALDH1A1LMNASLC9A1 | |
| SCHEMBL28230792 | 0.73 | P2RX7 (0.50) | HSD11B1P2RX7IDO1CDC7ALDH1A1 | |
| SCHEMBL11563985 | 0.73 | P2RX7 (0.50) | HSD11B1P2RX7IDO1CDC7ALDH1A1 | |
| SCHEMBL1371186 | 0.73 | KDM4E (0.54) | HSD11B1P2RX7IDO1CDC7ALDH1A1 | |
| SCHEMBL23336762 | 0.72 | HSD11B1 (0.55) | HSD11B1P2RX7IDO1CDC7ALDH1A1 | |
| SCHEMBL2895467 | 0.71 | CDC7 (0.61) | HSD11B1P2RX7IDO1CDC7ALDH1A1 | |
| SCHEMBL4195851 | 0.71 | HSD11B1 (0.61) | HSD11B1P2RX7IDO1CDC7ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095394-A1 | DIAZEPANES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2009-08-06 | — | — | WO | disclosed |
| WO-2009095394-A1 | DIAZEPANES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2009-08-06 | — | — | WO | disclosed |