Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.33 |
| ▸ | OGFRL1 | Q5TC84 | 5/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4199736 | 0.85 | GABRA1 (0.36) | GABRA1GABRA5OPRM1OPRK1OGFRL1 | |
| SCHEMBL4207843 | 0.83 | MAPK1 (0.35) | GABRA1GABRA5GABRG2GABRB3GABRA3 | |
| SCHEMBL4198619 | 0.69 | MEN1 (0.36) | GABRA1GABRA5GABRG2GABRB3GABRA3 | |
| SCHEMBL4198917 | 0.65 | RIPK1 (0.40) | KDM4EMAPT | |
| SCHEMBL19773424 | 0.62 | SMN1; SMN2 (0.39) | KDM4EALDH1A1MAPTHSD17B10NPC1 | |
| SCHEMBL28492842 | 0.60 | RIPK1 (0.47) | KDM4EALDH1A1MAPTALOX12HSD17B10 | |
| SCHEMBL108390 | 0.59 | MAPT (0.50) | ALDH1A1MAPTHSD17B10NPC1RAB9A | |
| SCHEMBL22277296 | 0.59 | SMN1; SMN2 (0.53) | CASP3CASP7CASP8NR1H2NR1H3 | |
| SCHEMBL20713807 | 0.59 | SMN1; SMN2 (0.53) | CASP3CASP7CASP8NR1H2NR1H3 | |
| SCHEMBL2589672 | 0.58 | MAPT (0.42) | KDM4EALDH1A1MAPTCASP1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758585-A4 | HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2009-07-22 | — | — | EP | disclosed |
| US-7476666-B2 | HIV integrase inhibitors | MERCK & CO., INC. (US) | 2009-01-13 | — | — | US | disclosed |
| US-20080015187-A1 | Hiv Integrase Inhibitors | MERCK SHARP & DOHME CORP. | 2008-01-17 | — | — | US | disclosed |
| EP-1758585-A2 | HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005120516-A2 | HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 2005-12-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015187-A1 | Hiv Integrase Inhibitors | REV1, ZC3HAV1, PNP | GABRA1 2247/4885GABRA5 2962/4885OPRM1 1662/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.