Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DUT | P33316 | 4/20 | 0.50 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.42 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.42 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.42 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.42 |
| ▸ | P2RY2 | P41231 | 6/20 | 0.38 |
| ▸ | P2RY6 | Q15077 | 2/20 | 0.38 |
| ▸ | P2RY4 | P51582 | 3/20 | 0.38 |
| ▸ | TK1 | P04183 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL41471 | 1.00 | DUT (0.50) | DUTSLC28A1SLC28A2SLC29A1SLC28A3 | |
| SCHEMBL3340603 | 1.00 | DUT (0.50) | DUTSLC28A1SLC28A2SLC29A1SLC28A3 | |
| SCHEMBL2557435 | 1.00 | DUT (0.50) | DUTSLC28A1SLC28A2SLC29A1SLC28A3 | |
| SCHEMBL6034458 | 0.91 | DUT (0.53) | DUTSLC28A1SLC28A2SLC29A1SLC28A3 | |
| SCHEMBL28745696 | 0.88 | DUT (0.51) | DUTSLC28A1SLC28A2SLC29A1SLC28A3 | |
| SCHEMBL249821 | 0.88 | DUT (0.51) | DUTSLC28A1SLC28A2SLC29A1SLC28A3 | |
| SCHEMBL10765602 | 0.88 | DUT (0.51) | DUTSLC28A1SLC28A2SLC29A1SLC28A3 | |
| SCHEMBL2056622 | 0.88 | DUT (0.51) | DUTSLC28A1SLC28A2SLC29A1SLC28A3 | |
| SCHEMBL15771583 | 0.88 | DUT (0.51) | DUTSLC28A1SLC28A2SLC29A1SLC28A3 | |
| SCHEMBL414704 | 0.88 | DUT (0.51) | DUTSLC28A1SLC28A2SLC29A1SLC28A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102307868-B | Indole derivatives as anticarcinogen | 詹森药业有限公司 | 2016-06-22 | — | — | CN | disclosed |
| CN-105229002-A | BET protein inhibiting dihydropyridopyrazinones | Bayer Pharma AG | 2016-01-06 | — | — | CN | disclosed |
| CN-105061598-A | anti-IL-1R 1 binding members | MEDIMMUNE LTD | 2015-11-18 | — | — | CN | disclosed |
| CN-104884472-A | Anti-vegf/dll4 dual variable domain immunoglobulins and uses thereof | ABBVIE INC | 2015-09-02 | — | — | CN | disclosed |
| CN-102307901-B | anti-IL-1R 1 binding members | MEDIMMUNE, LLC (GB) | 2015-08-19 | — | — | CN | disclosed |
| CN-101970424-B | Indolylpyridone derivatives with checkpoint kinase 1 inhibitory activity | VERNALIS R&D LTD | 2013-06-12 | — | — | CN | disclosed |
| CN-102459608-A | Combined engineering | BOEHRINGER INGELHEIM INT | 2012-05-16 | — | — | CN | disclosed |
| CN-102414320-A | Improved cell lines with reduced NOCR expression and uses thereof | BOEHRINGER INGELHEIM INT | 2012-04-11 | — | — | CN | disclosed |
| CN-102307901-A | anti-IL-1R 1 binding members | MEDIMMUNE LTD | 2012-01-04 | — | — | CN | disclosed |
| CN-102307868-A | Indole derivatives as anticancer agents | JANSSEN PHARMACEUTICA NV | 2012-01-04 | — | — | CN | disclosed |
| CN-101945867-A | Fused pyridine, pyrimidine and triazine compounds as cell cycle inhibitors | AMGEN INC | 2011-01-12 | — | — | CN | disclosed |
| CN-1976906-B | Substituted 2-alkyl quinazolinone derivatives as PARP inhibitors | JANSSEN PHARMACEUTICA NV | 2010-09-01 | — | — | CN | disclosed |
| US-7608402-B2 | DNA methylation specific signal amplification | LI WEIWEI | 2009-10-27 | — | — | US | disclosed |
| US-20090181373-A1 | DNA methylation specific signal amplification | LI WEIWEI | 2009-07-16 | — | — | US | disclosed |
| CN-101394844-A | Methoxypolyethylene glycol thioester chelate and uses thereof | EASTERN VIRGINIA MED SCHOOL (US) | 2009-03-25 | — | — | CN | disclosed |
| CN-101115727-A | Compounds for inhibition of CHK1 | ICOS CORP (US) | 2008-01-30 | — | — | CN | disclosed |
| CN-1976906-A | Substituted 2-alkyl quinazolinone derivatives as PARP inhibitors | JANSSEN PHARMACEUTICA NV (BE) | 2007-06-06 | — | — | CN | disclosed |
| CN-1367693-A | Pharmaceutical compositions containing poly(ADP-ribose) glycohydrolase inhibitors and method of using the same | GUILFORD PHARM INC (US) | 2002-09-04 | — | — | CN | disclosed |
| CN-1278797-A | Oxo-substituted compouns, process of making, and compositions and methods for inhibiting parp activity | GUILFORD PHARMACETICALS INC (US) | 2001-01-03 | — | — | CN | disclosed |
| CN-1277613-A | Poly (ADP-ribose) polymerase ('PARP') inhibitors, methods and pharmaceutical compositions for treating neural or cardiovascular tissue damage | GUILFORD PHARM INC (US) | 2000-12-20 | — | — | CN | disclosed |