Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.32 |
| ▸ | RELA | Q04206 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.32 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5710439 | 0.89 | LMNA (0.49) | LMNAPRMT5WDR77PKMALDH1A1 | |
| SCHEMBL30002590 | 0.85 | LMNA (0.40) | LMNAPRMT5WDR77PKMALDH1A1 | |
| SCHEMBL15055105 | 0.83 | MAPT (0.40) | LMNAPOLBMAPTP2RY6P2RY14 | |
| SCHEMBL891166 | 0.82 | LMNA (0.40) | LMNAPRMT5WDR77PKMALDH1A1 | |
| SCHEMBL15717320 | 0.79 | PDE4D (0.55) | LMNAPRMT5WDR77POLB | |
| SCHEMBL13160995 | 0.79 | PDE4D (0.55) | LMNAPRMT5WDR77POLB | |
| SCHEMBL5190899 | 0.78 | PDE4D (0.37) | LMNAALDH1A1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL15675784 | 0.78 | PDE4D (0.54) | LMNAPRMT5WDR77POLB | |
| SCHEMBL15675815 | 0.78 | PDE4D (0.54) | LMNAPRMT5WDR77POLB | |
| SCHEMBL4370139 | 0.78 | LMNA (0.54) | LMNAMAPTL3MBTL1P2RY6P2RY14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2032989-A2 | IGFBP2 BIOMARKER | SCHERING CORPORATION (US) | 2009-03-11 | — | — | EP | disclosed |
| WO-2008005469-A2 | IGFBP2 BIOMARKER | SCHERING CORPORATION (US) | 2008-01-10 | — | — | WO | disclosed |