Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCARB1 | Q8WTV0 | 5/20 | 0.67 |
| ▸ | RORC | P51449 | 2/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 9/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4188561 | 0.88 | SCARB1 (0.67) | SCARB1RORCPTGDR2NPC1HSD17B10 | |
| SCHEMBL4031809 | 0.84 | SCARB1 (0.62) | SCARB1RORCPTGDR2NPC1HSD17B10 | |
| SCHEMBL13746615 | 0.79 | SCARB1 (1.00) | SCARB1RORCPTGDR2CHRM2HTR1A | |
| SCHEMBL4197771 | 0.74 | SCARB1 (0.70) | SCARB1RORCPTGDR2NPC1HSD17B10 | |
| SCHEMBL4025480 | 0.74 | SCARB1 (0.61) | SCARB1RORCPTGDR2NPC1HSD17B10 | |
| SCHEMBL4728860 | 0.73 | SCARB1 (0.61) | SCARB1RORCPTGDR2 | |
| SCHEMBL10732414 | 0.73 | CHRM2 (0.64) | SCARB1RORCPTGDR2NPC1HSD17B10 | |
| SCHEMBL4195549 | 0.72 | SCARB1 (0.68) | SCARB1RORCPTGDR2NPC1HSD17B10 | |
| SCHEMBL4783197 | 0.72 | RORC (0.54) | SCARB1RORCNPC1HSD17B10 | |
| SCHEMBL4030252 | 0.72 | SCARB1 (0.70) | SCARB1RORCPTGDR2NPC1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |