Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GLS | O94925 | 1/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | IL2RA | P01589 | 1/20 | 0.35 |
| ▸ | ALB | P02768 | 1/20 | 0.35 |
| ▸ | IL2 | P60568 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.34 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324568 | 0.86 | POLB (0.50) | POLBSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL8553634 | 0.86 | POLB (0.45) | POLBSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL29812927 | 0.85 | SMN1; SMN2 (0.49) | POLBSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL4599962 | 0.85 | SMN1; SMN2 (0.49) | POLBSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL2125428 | 0.84 | POLB (0.48) | POLBSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL30089091 | 0.84 | POLB (0.48) | POLBSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL4204342 | 0.83 | LMNA (0.54) | POLBSMN1; SMN2LMNAMMP3MMP9 | |
| SCHEMBL30678922 | 0.83 | SMN1; SMN2 (0.47) | POLBSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL8800263 | 0.82 | POLB (0.46) | POLBSMN1; SMN2LMNAMEN1KMT2A | |
| SCHEMBL8799852 | 0.82 | POLB (0.46) | POLBSMN1; SMN2LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029578-A1 | 2-CARBOCYCLOAMINO-4-IMIDAZ0LYLPYRIMIDINES AS AGENTS FOR THE INHBITION OF CELL PROLIFERATION | AstraZeneca AB (SE) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007138277-A1 | 2-CARBOCYCLOAMINO-4-IMIDAZ0LYLPYRIMIDINES AS AGENTS FOR THE INHBITION OF CELL PROLIFERATION | ASTRAZENECA AB (SE) | 2007-12-06 | — | — | WO | disclosed |