Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 6/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | GHSR | Q92847 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4209408 | 0.89 | SMN1; SMN2 (0.47) | MAPK1POLBLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL4208341 | 0.87 | HTR6 (0.41) | MAPK1POLBLMNASMN1; SMN2TSHR | |
| SCHEMBL4209991 | 0.85 | HTR6 (0.38) | MAPK1POLBLMNASMN1; SMN2TSHR | |
| SCHEMBL4215742 | 0.85 | HTR6 (0.44) | MAPK1POLBLMNASMN1; SMN2TSHR | |
| SCHEMBL4200928 | 0.83 | SMN1; SMN2 (0.52) | POLBSMN1; SMN2ALDH1A1HTR6QRFPR | |
| SCHEMBL4205717 | 0.83 | GHSR (0.43) | LMNATSHRALDH1A1HTTGHSR | |
| SCHEMBL4207725 | 0.83 | TP53 (0.41) | MAPK1POLBGHSRHTR6QRFPR | |
| SCHEMBL4201683 | 0.83 | HTR6 (0.45) | MAPK1POLBSMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL4196128 | 0.82 | HTR6 (0.55) | MAPK1POLBLMNASMN1; SMN2TSHR | |
| SCHEMBL4204582 | 0.82 | TP53 (0.45) | MAPK1POLBLMNAGHSRHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090030038-A1 | Novel 8-Sulfonylamino-3 Aminosubstituted Chroman or Tetrahydronaphtalene Derivatives Modulating the 5Ht6 Receptor | ASTRAZENECA AB (SE) | 2009-01-29 | — | — | US | claimed |
| US-20090030038-A1 | Novel 8-Sulfonylamino-3 Aminosubstituted Chroman or Tetrahydronaphtalene Derivatives Modulating the 5Ht6 Receptor | ASTRAZENECA AB (SE) | 2009-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090030038-A1 | Novel 8-Sulfonylamino-3 Aminosubstituted Chroman or Tetrahydronaphtalene Derivatives Modulating the 5Ht6 Receptor | HTR6, HTR1A, HTR1D | MAPK1 3098/4885POLB 4768/4885LMNA 1549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.