SCHEMBL420702

SCHEMBL420702

C#CC(OC(=O)C(=C)C)[Si](C)(C)C

nearest known ligand 0.37

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.37
TSHR P16473 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8956945 0.80 ALDH1A1 (0.42) ALDH1A1TSHR
SCHEMBL11114493 0.77
SCHEMBL25140038 0.75 ALDH1A1 (0.42) ALDH1A1TSHR
SCHEMBL8993196 0.74 ALDH1A1 (0.41) ALDH1A1TSHR
SCHEMBL1252608 0.74 TSHR (0.47) ALDH1A1TSHR
SCHEMBL1773558 0.73 ALDH1A1 (0.44) ALDH1A1TSHR
SCHEMBL10719831 0.73 ALDH1A1 (0.44) ALDH1A1TSHR
SCHEMBL145421 0.71 TSHR (0.43) ALDH1A1TSHR
SCHEMBL1677860 0.71 TSHR (0.39) ALDH1A1TSHR
SCHEMBL11706949 0.68 ALDH1A1 (0.45) ALDH1A1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9211250-B2 Heterogeneous polymeric micelles for intracellular delivery UNIVERSITY OF WASHINGTON (US) 2015-12-15 US disclosed
US-8197847-B2 Process for making polymers and supports comprising pendant sugar side groups WARWICK EFFECT POLYMERS LTD. (GB) 2012-06-12 US disclosed
US-20120021514-A1 HETEROGENEOUS POLYMERIC MICELLES FOR INTRACELLULAR DELIVERY PHASERX, INC. (US) 2012-01-26 US disclosed
EP-2331069-A1 HETEROGENEOUS POLYMERIC MICELLES FOR INTRACELLULAR DELIVERY University Of Washington (US) 2011-06-15 EP disclosed
WO-2010021770-A1 HETEROGENEOUS POLYMERIC MICELLES FOR INTRACELLULAR DELIVERY UNIVERSITY OF WASHINGTON (US) 2010-02-25 WO disclosed
US-20090082224-A1 POLYMERS WARWICK EFFECT POLYMERS LIMITED (GB) 2009-03-26 US disclosed