Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 6/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16972853 | 0.86 | CAPN1 (0.47) | KDM4EKMT2ACAPN1ALDH1A1RAB9A | |
| SCHEMBL27823277 | 0.85 | KDM4E (0.56) | ABCB1KDM4EMEN1USP2TSHR | |
| SCHEMBL14330483 | 0.84 | ELANE (0.49) | KDM4EMEN1TSHRKMT2AHSD17B10 | |
| SCHEMBL3029800 | 0.84 | HCRTR1 (0.62) | ABCB1KDM4EMEN1USP2TSHR | |
| SCHEMBL30070812 | 0.84 | ELANE (0.49) | KDM4EMEN1TSHRKMT2AHSD17B10 | |
| SCHEMBL12379193 | 0.83 | NPC1 (0.54) | KDM4EKMT2AHSD17B10CAPN1ALDH1A1 | |
| SCHEMBL2290756 | 0.82 | ALDH1A1 (0.61) | KDM4EMEN1USP2TSHRKMT2A | |
| SCHEMBL2047902 | 0.82 | LMNA (0.64) | ABCB1KDM4EALDH1A1POLBLMNA | |
| SCHEMBL29738645 | 0.82 | NPC1 (0.64) | KMT2AALDH1A1RAB9ANPC1LMNA | |
| SCHEMBL878658 | 0.82 | NPC1 (0.64) | KMT2AALDH1A1RAB9ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103951633-B | Mitotic kinesin inhibitors and methods of use thereof | 阿雷生物药品公司 | 2017-05-10 | — | — | CN | disclosed |
| CN-103626720-B | Mitotic kinesin inhibitors and using method thereof | 阿雷生物药品公司 | 2016-11-16 | — | — | CN | disclosed |
| CN-103951633-A | Mitotic kinesin inhibitors and methods of use thereof | ARRAY BIOPHARMA INC | 2014-07-30 | — | — | CN | disclosed |
| CN-103626720-A | Mitotic kinesin inhibitors and methods of use thereof | ARRAY BIOPHARMA INC | 2014-03-12 | — | — | CN | disclosed |
| CN-101309912-B | Oxazole compound and pharmaceutical composition | OTSUKA PHARMA CO LTD | 2013-09-25 | — | — | CN | disclosed |
| CN-1543455-B | 3-phenoxy-4-pyridazinol derivatives and herbicidal compositions containing the same | SANKYO AGRO CO LTD | 2012-07-11 | — | — | CN | disclosed |
| CN-102532051-A | Mitotic kinesin inhibitors and methods of use thereof | ARRAY BIOPHARMA INC | 2012-07-04 | — | — | CN | disclosed |
| US-20090156646-A1 | PYRIDYLPHENOL COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-18 | — | — | US | disclosed |
| CN-101309912-A | Oxazole compound and pharmaceutical composition | OTSUKA PHARMA CO LTD (JP) | 2008-11-19 | — | — | CN | disclosed |
| EP-1921066-A1 | PYRIDYLPHENOL COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2008-05-14 | — | — | EP | disclosed |
| CN-101083988-A | Mitotic kinesin inhibitors and methods of use thereof | ARRAY BIOPHARMA INC (US) | 2007-12-05 | — | — | CN | disclosed |
| CN-1543455-A | 3-phenoxy-4-pyridazinol derivatives and herbicidal compositions containing the same | 三共农业株式会社 | 2004-11-03 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156646-A1 | PYRIDYLPHENOL COMPOUND AND USE THEREOF | GNRHR, PGR, MC1R | ABCB1 3681/4885KDM4E 881/4885MEN1 64/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.