Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1E | P49674 | 3/20 | 0.49 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.49 |
| ▸ | CSNK1G3 | Q9Y6M4 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CNR2 | P34972 | 3/20 | 0.43 |
| ▸ | CNR1 | P21554 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2187098 | 0.83 | CSNK1E (0.51) | CSNK1ECSNK1DCSNK1G3NPSR1SMN1; SMN2 | |
| SCHEMBL2187121 | 0.82 | CSNK1E (0.48) | CSNK1ECSNK1DCSNK1G3KMT2AALDH1A1 | |
| SCHEMBL15541991 | 0.80 | CSNK1E (0.60) | CSNK1ECSNK1DCSNK1G3MEN1KMT2A | |
| SCHEMBL2188423 | 0.80 | CSNK1E (0.56) | CSNK1ECSNK1DCSNK1G3NPSR1MEN1 | |
| SCHEMBL2188622 | 0.80 | CSNK1E (0.53) | CSNK1ECSNK1DCSNK1G3TP53SMN1; SMN2 | |
| SCHEMBL420828 | 0.77 | CSNK1E (0.59) | CSNK1ECSNK1DCSNK1G3MEN1KMT2A | |
| SCHEMBL27698601 | 0.76 | CSNK1E (0.49) | CSNK1ECSNK1DCSNK1G3SMN1; SMN2CNR2 | |
| SCHEMBL15541229 | 0.73 | SMN1; SMN2 (0.64) | CSNK1ECSNK1DCSNK1G3NPSR1MEN1 | |
| SCHEMBL2188562 | 0.71 | LMNA (0.67) | NPSR1MEN1KMT2ATP53SMN1; SMN2 | |
| SCHEMBL2187471 | 0.70 | CSNK1E (0.57) | CSNK1ECSNK1DCSNK1G3NPSR1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101031567-B | Novel heterocyclic NF-kB inhibitors | 4SC Corp.,Ltd. (DE) | 2011-12-21 | — | — | CN | disclosed |
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |
| CN-101405278-A | Novel heterocyclic NF-kB inhibitors | 4SC AG (DE) | 2009-04-08 | — | — | CN | disclosed |
| CN-101233119-A | Novel heterocyclic nf-kb inhibitors | 4SC AG (DE) | 2008-07-30 | — | — | CN | disclosed |
| CN-101031567-A | Novel heterocyclic NF-kB inhibitors | 4SC AG (DE) | 2007-09-05 | — | — | CN | disclosed |