Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 5/20 | 0.47 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.45 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 4/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4029830 | 0.80 | SCARB1 (0.46) | PTGER4KDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL4024468 | 0.78 | ALDH1A1 (0.55) | PTGER4AKR1B10AKR1B1KDM4EALDH1A1 | |
| SCHEMBL29493320 | 0.73 | PTGER4 (0.73) | MAOAMAOBHTR6GRIK2PTGER4 | |
| SCHEMBL21651446 | 0.73 | PTGER4 (0.73) | MAOAMAOBHTR6GRIK2PTGER4 | |
| SCHEMBL13746711 | 0.69 | KMT2A (0.47) | KDM4EALDH1A1HTTMEN1KMT2A | |
| SCHEMBL15466317 | 0.66 | MAPT (0.68) | GRIK2PTGER4GRIK1KDM4EPOLB | |
| SCHEMBL29643325 | 0.66 | MAPT (0.68) | GRIK2PTGER4GRIK1KDM4EPOLB | |
| SCHEMBL11290872 | 0.66 | GRIK2 (0.68) | GRIK2PTGER4GRIK1KDM4EPOLB | |
| SCHEMBL4108440 | 0.66 | KDM4E (0.40) | MAOAMAOBHTR6HRH1KDM4E | |
| SCHEMBL4117732 | 0.66 | AKR1B1 (0.47) | AKR1B10AKR1B1KDM4EPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |