Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCARB1 | Q8WTV0 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | RORC | P51449 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 5/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4024468 | 0.87 | ALDH1A1 (0.55) | KDM4ERORCHSD17B10ALDH1A1TSHR | |
| SCHEMBL6756508 | 0.82 | SCARB1 (0.63) | SCARB1KDM4ERORCHSD17B10ALDH1A1 | |
| SCHEMBL4209635 | 0.80 | MAOA (0.48) | KDM4EHSD17B10ALDH1A1PTGER4MEN1 | |
| SCHEMBL13746711 | 0.79 | KMT2A (0.47) | KDM4ERORCALDH1A1HPGDMEN1 | |
| SCHEMBL4023279 | 0.79 | SCARB1 (0.49) | SCARB1KDM4EALDH1A1HPGDMAPKAPK2 | |
| SCHEMBL4195183 | 0.77 | SCARB1 (0.52) | SCARB1KDM4EHSD17B10MAPKAPK2CNR2 | |
| SCHEMBL22511693 | 0.74 | RORC (0.56) | SCARB1KDM4ERORCHSD17B10ALDH1A1 | |
| SCHEMBL4199593 | 0.73 | SCARB1 (0.38) | SCARB1KDM4ERORCHSD17B10ALDH1A1 | |
| SCHEMBL4728729 | 0.71 | PTGER4 (0.69) | SCARB1KDM4ERORCALDH1A1HPGD | |
| SCHEMBL541347 | 0.70 | AKR1B10 (0.61) | KDM4EHSD17B10ALDH1A1HPGDPTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009103022-A1 | DERIVATIVES OF SUBSTITUTED FUSED RING CYCLOINDOLES AND METHODS OF THEIR USE | ITHERX PHARMACEUTICALS, INC. (US) | 2009-08-20 | — | — | WO | disclosed |
| WO-2008021745-A2 | HEPATITIS C VIRUS ENTRY INHIBITORS | ITHERX PHARMACEUTICALS, INC. (US) | 2008-02-21 | — | — | WO | disclosed |