Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | ALPI | P09923 | 1/20 | 0.42 |
| ▸ | ALPG | P10696 | 1/20 | 0.42 |
| ▸ | MPI | P34949 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9851979 | 0.72 | GAA (1.00) | GAAKDM4EHSD17B10CYP1A2CYP3A4 | |
| SCHEMBL5378866 | 0.69 | GAA (0.43) | GAAKDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL11636643 | 0.68 | HSD17B10 (0.70) | GAAKDM4EHSD17B10CYP1A2CYP3A4 | |
| SCHEMBL5380332 | 0.67 | METAP2 (0.42) | GAAALDH1A1LMNAPOLBRAB9A | |
| SCHEMBL5762792 | 0.67 | HPGD (0.33) | ALDH1A1LMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL5915237 | 0.67 | DAO (0.39) | GAACYP2C19PKMLMNAPOLB | |
| SCHEMBL4202526 | 0.67 | KDM4E (0.40) | KDM4ECYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL12242700 | 0.64 | — | — | |
| SCHEMBL11233527 | 0.63 | ALDH1A1 (0.40) | HSD17B10ALDH1A1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL5311448 | 0.62 | KDM4E (0.51) | GAAKDM4EHSD17B10CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379240-A4 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORP (US) | 2009-04-08 | — | — | EP | claimed |
| JP-2005506299-A | — | — | 2005-03-03 | — | — | JP | claimed |
| EP-1379240-A1 | COMPOUNDS AND METHODS | SmithKline Beecham Corporation (US) | 2004-01-14 | — | — | EP | claimed |
| WO-2002078696-A1 | COMPOUNDS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-10 | — | — | WO | claimed |