Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR3 | O14843 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | KCNA4 | P22459 | 1/20 | 0.38 |
| ▸ | KCNA1 | Q09470 | 1/20 | 0.38 |
| ▸ | KCNAB1 | Q14722 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | THPO | P40225 | 1/20 | 0.36 |
| ▸ | STAT6 | P42226 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | GMNN | O75496 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL15522635 | 0.97 | FFAR3 (0.50) | FFAR3MAPK1KCNA4KCNA1KCNAB1 | |
| SCHEMBL1823909 | 0.82 | FFAR3 (0.46) | FFAR3MAPK1CYP2C19SMN1; SMN2NPSR1 | |
| SCHEMBL1826703 | 0.82 | FFAR3 (0.46) | FFAR3MAPK1CYP2C19SMN1; SMN2NPSR1 | |
| SCHEMBL1826359 | 0.82 | FFAR3 (0.46) | FFAR3MAPK1CYP2C19SMN1; SMN2NPSR1 | |
| SCHEMBL9708741 | 0.81 | FFAR3 (0.38) | FFAR3MAPK1KCNA4KCNA1KCNAB1 | |
| SCHEMBL1970312 | 0.80 | KCNA4 (0.39) | FFAR3KCNA4KCNA1KCNAB1 | |
| SCHEMBL353254 | 0.80 | — | — | |
| SCHEMBL7258460 | 0.78 | KCNA4 (0.43) | FFAR3MAPK1KCNA4KCNA1KCNAB1 | |
| SCHEMBL28017602 | 0.77 | FFAR3 (0.35) | FFAR3MAPK1KCNA4KCNA1KCNAB1 | |
| SCHEMBL16153587 | 0.76 | KCNA4 (0.37) | FFAR3KCNA4KCNA1KCNAB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 379 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113527646-B | Self-repairable furan group-containing bio-based unsaturated polyester resin and preparation method and application thereof | 四川大学 | 2022-04-01 | — | — | CN | claimed |
| CN-113527646-A | Self-repairable furan group-containing bio-based unsaturated polyester resin and preparation method and application thereof | 四川大学 | 2021-10-22 | — | — | CN | claimed |
| CN-113372325-A | Temsirolimus intermediate compound III | 鲁南制药集团股份有限公司 | 2021-09-10 | — | — | CN | claimed |
| CN-113372375-A | Preparation method of temsirolimus intermediate | 鲁南制药集团股份有限公司 | 2021-09-10 | — | — | CN | claimed |
| CN-108948046-B | Intermediate of temsirolimus and preparation method thereof | 鲁南制药集团股份有限公司 | 2020-11-10 | — | — | CN | claimed |
| CN-108997563-A | A kind of method of ROMP polymerization preparation based polyalcohol containing POSS | 上海应用技术大学 | 2018-12-14 | — | — | CN | claimed |
| CN-108948045-A | A kind of preparation method of tesirolimus | 鲁南制药集团股份有限公司 | 2018-12-07 | — | — | CN | claimed |
| US-RE44768-E1 | Rapamycin hydroxyesters | WYETH LLC (US) | 2014-02-18 | — | — | US | claimed |
| US-8258299-B2 | Process for preparation of temsirolimus | Chungwa Chemical Synthesis & Biotech Co., Ltd. (TW) | 2012-09-04 | — | — | US | claimed |
| US-20100249415-A1 | Process for preparation of temsirolimus | CHUNGHWA CHEMICAL SYNTHESIS & BIOTECH CO., LTD. (TW) | 2010-09-30 | — | — | US | claimed |
| EP-1266899-B1 | Rapamycin hdroxyesters, process for their preparation and pharmaceutical compositions containing them | WYETH CORP (US) | 2007-01-03 | — | — | EP | claimed |
| EP-1216251-B1 | REGIOSELECTIVE SYNTHESIS OF RAPAMYCIN DERIVATIVES | WYETH CORP (US) | 2003-02-26 | — | — | EP | claimed |
| EP-1266899-A2 | Rapamycin hdroxyesters, process for their preparation and pharmaceutical compositions containing them | Wyeth (US) | 2002-12-18 | — | — | EP | claimed |
| EP-1216251-A2 | REGIOSELECTIVE SYNTHESIS OF RAPAMYCIN DERIVATIVES | Wyeth (US) | 2002-06-26 | — | — | EP | claimed |
| US-20010039338-A1 | Regioselective synthesis of rapamycin derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-11-08 | — | — | US | claimed |
| US-6277983-B1 | Regioselective synthesis of rapamycin derivatives | AMERICAN HOME PRODUCTS CORPORATION | 2001-08-21 | — | — | US | claimed |
| WO-2001023395-A2 | REGIOSELECTIVE SYNTHESIS OF RAPAMYCIN DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-04-05 | — | — | WO | claimed |
| EP-0763039-A1 | RAPAMYCIN HYDROXYESTERS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-03-19 | — | — | EP | claimed |
| WO-1995028406-A1 | RAPAMYCIN HYDROXYESTERS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | AMERICAN HOME PRODUCTS CORPORATION (US) | 1995-10-26 | — | — | WO | claimed |
| US-5362718-A | Rapamycin hydroxyesters | AMERICAN HOME PRODUCTS CORPORATION (US) | 1994-11-08 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249415-A1 | Process for preparation of temsirolimus | RICTOR, MTOR, MLST8 | FFAR3 2588/4885MAPK1 828/4885KCNA4 4251/4885 |
| US-20010039338-A1 | Regioselective synthesis of rapamycin derivatives | RICTOR, MTOR, RPTOR | FFAR3 1979/4885MAPK1 659/4885KCNA4 4514/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.