Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Chlorpheniramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 6/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 6/20 | 1.00 |
| ▸ | SLC6A4 | P31645 | 6/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 5/20 | 1.00 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 4/20 | 1.00 |
| ▸ | ADRA2B | P18089 | 4/20 | 1.00 |
| ▸ | HTR2A | P28223 | 3/20 | 1.00 |
| ▸ | SCN1A | P35498 | 3/20 | 1.00 |
| ▸ | SCN2A | Q99250 | 3/20 | 1.00 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 3/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 2/20 | 1.00 |
| ▸ | HRH2 | P25021 | 2/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 2/20 | 1.00 |
| ▸ | THPO | P40225 | 2/20 | 1.00 |
| ▸ | HTR2C | P28335 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dexchlorpheniramine SCHEMBL3538 | 1.00 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4HRH1SLC6A3 | |
| Chlorpheniramine SCHEMBL4314182 | 1.00 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4HRH1SLC6A3 | |
| Chlorpheniramine SCHEMBL20956397 | 1.00 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4HRH1SLC6A3 | |
| Chlorpheniramine SCHEMBL4220 | 1.00 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4HRH1SLC6A3 | |
| Chlorpheniramine SCHEMBL29687335 | 1.00 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4HRH1SLC6A3 | |
| Chlorpheniramine SCHEMBL5022351 | 0.99 | CHRM2 (0.97) | CHRM2SLC6A2SLC6A4HRH1SLC6A3 | |
| Chlorpheniramine SCHEMBL14879822 | 0.99 | CHRM2 (0.97) | CHRM2SLC6A2SLC6A4HRH1SLC6A3 | |
| Chlorpheniramine SCHEMBL506017 | 0.99 | CHRM2 (0.97) | CHRM2SLC6A2SLC6A4HRH1SLC6A3 | |
| Chlorpheniramine SCHEMBL10622596 | 0.99 | CHRM2 (0.97) | CHRM2SLC6A2SLC6A4HRH1SLC6A3 | |
| Chlorpheniramine SCHEMBL14879823 | 0.99 | CHRM2 (0.97) | CHRM2SLC6A2SLC6A4HRH1SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 45679 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4570760-B1 | COMPOSITION OF AN ULTRA-PURE ZINC BROMIDE AND ZINC CHLORIDE BLEND PRODUCED FROM A METHOD OF REACTING CHLORINE WITH A MIXTURE OF ZINC BROMIDE AND ZINC | TETRA TECH (US) | 2026-05-27 | — | — | EP | claimed |
| EP-3607938-B1 | PHARMACEUTICAL COMPOSITION | SOVIC BRKICIC LJILJANA (HR) | 2026-05-27 | — | — | EP | claimed |
| CN-116898754-B | Composition for water-based cosmetic, essence containing composition and preparation method of essence | Ma Yinglong health Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122075378-A | Antioxidant composition and application thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122072257-A | Method for rapidly detecting poison in blood | 中国科学院大连化学物理研究所 | 2026-05-22 | — | — | CN | claimed |
| WO-2026102563-A1 | DISUBSTITUTED PYRIMIDOPYRROLE ANALOG AND USE THEREOF | 深圳湾实验室坪山生物医药研发转化中心 | 2026-05-21 | — | — | WO | claimed |
| US-20260139860-A1 | PRODUCTS OF MANUFACTURE FOR THE TREATMENT, PREVENTION AND AMELIORATION OF MICROBIAL INFECTIONS | CENTRE FOR DIGESTIVE DISEASES (AU) | 2026-05-21 | — | — | US | claimed |
| CN-122056798-A | Skin care product composition containing deep seawater mineral powder and preparation method and application thereof | 后羿生物医药(杭州)有限公司 | 2026-05-19 | — | — | CN | claimed |
| WO-2026100654-A1 | NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD | 株式会社インファーマシア | 2026-05-15 | — | — | WO | claimed |
| CN-122042580-A | Construction method of core-shell structure photonic crystal microneedle sensor for jellyfish stings treatment | 青岛科技大学 | 2026-05-15 | — | — | CN | claimed |
| EP-0028184-A1 | Retracting device for partitioning panel | AUTOMOBILES CITROEN (FR) | 1981-05-06 | — | — | EP | claimed |
| US-4234566-A | Antihistamine and methods for use thereof | CARTER-WALLACE, INC. | 1980-11-18 | — | — | US | claimed |
| US-4232002-A | Procedures and pharmaceutical products for use in the administration of antihistamines | THE WELSH NATIONAL SCHOOL OF MEDICINE (GB) | 1980-11-04 | — | — | US | claimed |
| EP-0017515-A1 | Automatic moving and locking device, especially for the rear-door of a motor vehicle | REGIE NATIONALE DES USINES RENAULT (FR) | 1980-10-15 | — | — | EP | claimed |
| US-4226850-A | ANTIHISTAMINES | CARTER-WALLACE, INC., A CORP. OF DE | 1980-10-07 | — | — | US | claimed |
| EP-0012633-A1 | Locking and unlatching assembly for the lid of a vehicle boot | REGIE NATIONALE DES USINES RENAULT (FR) | 1980-06-25 | — | — | EP | claimed |
| US-4205060-A | Microcapsules containing medicament-polymer salt having a water-insoluble polymer sheath, their production and their use | PENNWALT CORPORATION (US) | 1980-05-27 | — | — | US | claimed |
| US-4175119-A | Composition and method to prevent accidental and intentional overdosage with psychoactive drugs | PORTER GARRY L | 1979-11-20 | — | — | US | claimed |
| US-4104382-A | (((THIAZOLYL-, ISOTHIAZOLYL- OR PYRIDYLALKYL)THIO)ALKYL)GUANIDINE | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1978-08-01 | — | — | US | claimed |
| US-4000302-A | ANTIHISTAMINES | SMITH KLINE & FRENCH LABORATORIES LIMITED (EN) | 1976-12-28 | — | — | US | claimed |