Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Chlorpheniramine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.97 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.97 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.97 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.97 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.97 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.97 |
| ▸ | HTR2A | P28223 | 3/20 | 0.97 |
| ▸ | SCN1A | P35498 | 3/20 | 0.97 |
| ▸ | SCN2A | Q99250 | 3/20 | 0.97 |
| ▸ | SCN3A | Q9NY46 | 3/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.97 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.97 |
| ▸ | HRH2 | P25021 | 2/20 | 0.97 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.97 |
| ▸ | THPO | P40225 | 2/20 | 0.97 |
| ▸ | HTR2C | P28335 | 2/20 | 0.97 |
| ▸ | TSHR | P16473 | 2/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlorpheniramine SCHEMBL20956397 | 0.99 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4HRH1SLC6A3 | |
| Dexchlorpheniramine SCHEMBL3538 | 0.99 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4HRH1SLC6A3 | |
| Chlorpheniramine SCHEMBL4220 | 0.99 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4HRH1SLC6A3 | |
| Chlorpheniramine SCHEMBL4219 | 0.99 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4HRH1SLC6A3 | |
| Chlorpheniramine SCHEMBL29687335 | 0.99 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4HRH1SLC6A3 | |
| Chlorpheniramine SCHEMBL4314182 | 0.99 | CHRM2 (1.00) | CHRM2SLC6A2SLC6A4HRH1SLC6A3 | |
| Chlorpheniramine SCHEMBL14879822 | 0.97 | CHRM2 (0.97) | CHRM2SLC6A2SLC6A4HRH1SLC6A3 | |
| Chlorpheniramine SCHEMBL506017 | 0.97 | CHRM2 (0.97) | CHRM2SLC6A2SLC6A4HRH1SLC6A3 | |
| Chlorpheniramine SCHEMBL10622596 | 0.97 | CHRM2 (0.97) | CHRM2SLC6A2SLC6A4HRH1SLC6A3 | |
| Chlorpheniramine SCHEMBL14879823 | 0.97 | CHRM2 (0.97) | CHRM2SLC6A2SLC6A4HRH1SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080286388-A1 | Pharmaceutical Composition and Non Dependence Coffee Comprising Edible Carboxylic Acid and/or Its Acid Salts and Coffeine | SHIAO SHIN-JEN | 2008-11-20 | — | — | US | disclosed |
| US-20060251703-A1 | Composition comprising an edible acid or its acidic salt and the use thereof | SHIAO SHIN-JEN | 2006-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060251703-A1 | Composition comprising an edible acid or its acidic salt and the use thereof | CMA1, CHIA, TNF | HRH1 37/4885CHRM2 2903/4885SLC6A2 1093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.