Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | GRM5 | P41594 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CDK2AP1 | O14519 | 1/20 | 0.48 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | WNT1 | P04628 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | ANPEP | P15144 | 2/20 | 0.47 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16731036 | 1.00 | ALDH1A1 (0.59) | ALDH1A1L3MBTL1MAPTHTTGRM5 | |
| SCHEMBL4221004 | 1.00 | ALDH1A1 (0.59) | ALDH1A1L3MBTL1MAPTHTTGRM5 | |
| SCHEMBL8863954 | 0.92 | ALDH1A1 (0.65) | ALDH1A1L3MBTL1MAPTHTTGRM5 | |
| SCHEMBL1116630 | 0.84 | ALDH1A1 (0.78) | ALDH1A1L3MBTL1MAPTHTTGRM5 | |
| SCHEMBL241357 | 0.82 | HDAC4 (0.53) | ALDH1A1L3MBTL1GRM5CDK2AP1CHEK1 | |
| SCHEMBL241356 | 0.82 | HDAC4 (0.53) | ALDH1A1L3MBTL1GRM5CDK2AP1CHEK1 | |
| SCHEMBL1250846 | 0.82 | MEN1 (0.54) | GRM5SMN1; SMN2RAB9A | |
| SCHEMBL5230051 | 0.82 | MEN1 (0.54) | GRM5SMN1; SMN2RAB9A | |
| SCHEMBL8491815 | 0.82 | MEN1 (0.54) | GRM5SMN1; SMN2RAB9A | |
| SCHEMBL10767187 | 0.81 | HTT (0.64) | ALDH1A1L3MBTL1MAPTHTTGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090240045-A1 | Organic Compounds | NOVARTIS AG | 2009-09-24 | — | — | US | disclosed |
| US-20080242683-A1 | Organic Compounds | NOVARTIS AG (CH) | 2008-10-02 | — | — | US | disclosed |
| EP-1861412-A1 | ADENOSINE DERIVATIVES HAVING A2A RECEPTOR ACTIVITY | Novartis AG (CH) | 2007-12-05 | — | — | EP | disclosed |
| WO-2006097260-A1 | ADENOSINE DERIVATIVES HAVING A2A RECEPTOR ACTIVITY | NOVARTIS AG (CH) | 2006-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080242683-A1 | Organic Compounds | ADORA2A, ADORA3, ADORA1 | ALDH1A1 387/4885L3MBTL1 3197/4885MAPT 4355/4885 |
| US-20090240045-A1 | Organic Compounds | CYP3A43, CYP3A4, SLCO1B3 | ALDH1A1 301/4885L3MBTL1 2443/4885MAPT 1867/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.