SCHEMBL422152

SCHEMBL422152

COc1cc(NS(=O)(=O)c2ccc(Cl)cc2)c(C(=O)Nc2ccc(S(=O)(=O)N3CCSCC3)cc2)cc1OC

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.59
KDM4E B2RXH2 2/20 0.59
MEN1 O00255 4/20 0.53
KMT2A Q03164 4/20 0.53
LMNA P02545 3/20 0.53
MAPK1 P28482 2/20 0.53
HSD17B10 Q99714 2/20 0.53
SMN1; SMN2 Q16637 1/20 0.52
POLB P06746 2/20 0.51
AVPR2 P30518 1/20 0.51
GPR27 Q9NS67 1/20 0.51
SLC10A2 Q12908 1/20 0.50
SLC10A1 Q14973 1/20 0.50
SLC10A6 Q3KNW5 1/20 0.50
MAPT P10636 2/20 0.49
USP2 O75604 1/20 0.49
GAA P10253 1/20 0.49
HTT P42858 1/20 0.49
HPGD P15428 1/20 0.49
NPSR1 Q6W5P4 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29382580 1.00 ALDH1A1 (0.59) ALDH1A1KDM4EMEN1KMT2ALMNA
SCHEMBL491894 0.95 ALDH1A1 (0.55) ALDH1A1KDM4EMEN1KMT2ALMNA
SCHEMBL12585305 0.94 ALDH1A1 (0.57) ALDH1A1KDM4EMEN1KMT2ALMNA
SCHEMBL10256187 0.92 ALDH1A1 (0.54) ALDH1A1KDM4EMEN1KMT2ALMNA
SCHEMBL491822 0.91 ALDH1A1 (0.59) ALDH1A1KDM4EMEN1KMT2ALMNA
SCHEMBL28461951 0.91 ALDH1A1 (0.49) ALDH1A1KDM4EMEN1KMT2ALMNA
SCHEMBL490922 0.90 ALDH1A1 (0.60) ALDH1A1KDM4EMEN1KMT2ALMNA
SCHEMBL492244 0.89 KMT2A (0.62) ALDH1A1KDM4EMEN1KMT2ALMNA
SCHEMBL28643129 0.89 ALDH1A1 (0.56) ALDH1A1KDM4EMEN1KMT2ALMNA
SCHEMBL491750 0.89 KMT2A (0.64) ALDH1A1KDM4EMEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 343 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220211702-A1 METHODS AND MATERIALS FOR GENDER-DEPENDENT TREATMENT OF CARDIOVASCULAR DYSFUNCTION MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH 2022-07-07 US claimed
US-20220128561-A1 METHODS TO DETERMINE WHETHER A SUBJECT IS SUITABLE OF BEING TREATED WITH AN AGONIST OF SOLUBLE GYANYLYL CYCLASE (SGC) BAYER AKTIENGESELLSCHAFT (DE) 2022-04-28 US claimed
EP-3911675-A1 METHODS TO DETERMINE WHETHER A SUBJECT IS SUITABLE OF BEING TREATED WITH AN AGONIST OF SOLUBLE GUANYLYL CYCLASE (SGC) Bayer Aktiengesellschaft (DE) 2021-11-24 EP claimed
WO-2020148379-A1 METHODS TO DETERMINE WHETHER A SUBJECT IS SUITABLE OF BEING TREATED WITH AN AGONIST OF SOLUBLE GUANYLYL CYCLASE (SGC) BAYER AKTIENGESELLSCHAFT (DE) 2020-07-23 WO claimed
US-20180169095-A1 THE USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF DIGITAL ULCERS (DU) CONCOMITANT TO SYSTEMIC SCLEROSIS (SSC) BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2018-06-21 US claimed
EP-3291811-A1 THE USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF DIGITAL ULCERS (DU) CONCOMITANT TO SYSTEMIC SCLEROSIS (SSC) Bayer Pharma Aktiengesellschaft (DE) 2018-03-14 EP claimed
WO-2016177660-A1 THE USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF DIGITAL ULCERS (DU) CONCOMITANT TO SYSTEMIC SCLEROSIS (SSC) BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-11-10 WO claimed
US-20160158233-A1 SGC STIMULATORS OR SGC ACTIVATORS AND PDE5 INHIBITORS IN COMBINATION WITH ADDITIONAL TREATMENT FOR THE THERAPY OF CYSTIC FIBROSIS BAYER PHARMA AKTIENGESELl SCHAFT (DE) 2016-06-09 US claimed
EP-3024455-A1 SGC STIMULATORS OR SGC ACTIVATORS AND PDE5 INHIBITORS IN COMBINATION WITH ADDITIONAL TREATMENT FOR THE THERAPY OF CYSTIC FIBROSIS Bayer Pharma Aktiengesellschaft (DE) 2016-06-01 EP claimed
EP-2531187-B1 sGC STIMULATORS OR sGC ACTIVATORS ALONE AND IN COMBINATION WITH PDE5 INHBITORS FOR THE TREATMENT OF CYSTIC FIBROSIS ADVERIO PHARMA GMBH (DE) 2015-08-12 EP claimed
EP-2207541-A1 USE OF SULFONYL-SUBSTITUTED 2-SULFONYLAMINOBENZOIC ACID N-PHENYLAMIDES IN THE TREATMENT OF PAIN Sanofi-Aventis Deutschland GmbH (DE) 2010-07-21 EP claimed
US-20100144864-A1 SOLUBLE GUANYLATE CYCLASE (SGC) MODULATORS FOR TREATMENT OF LIPID RELATED DISORDERS IRONWOOD PHARMACEUTICALS, INC. (US) 2010-06-10 US claimed
WO-2009043495-A1 USE OF SULFONYL-SUBSTITUTED 2-SULFONYLAMINOBENZOIC ACID N-PHENYLAMIDES IN THE TREATMENT OF PAIN SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) 2009-04-09 WO claimed
WO-2008157537-A2 COMPOSITIONS AND METHODS OF USE FOR TREATING OR PREVENTING LIPID RELATED DISORDERS IRONWOOD PHARMACEUTICALS, INC (US) 2008-12-24 WO claimed
WO-2008124505-A2 SOLUBLE GUANYLATE CYCLASE (SGC) MODULATORS FOR TREATMENT OF LIPID RELATED DISORDERS IRONWOOD PHARMACEUTICALS,INC. (US) 2008-10-16 WO claimed
US-20080096936-A1 Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them TELEVOX SOFTWARE, INCORPORATED 2008-04-24 US claimed
EP-1095016-B1 SULFUR SUBSTITUTED SULFONYLAMINOCARBOXYLIC ACID N-ARYLAMIDES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM SANOFI AVENTIS DEUTSCHLAND (DE) 2005-11-09 EP claimed
US-20040186145-A1 Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them AVENTIS PHARMA DEUTSCHLAND GMBH. 2004-09-23 US claimed
US-20020061887-A1 Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them AVENTIS PHARMA DEUTSCHLAND GMBH 2002-05-23 US claimed
US-6335334-B1 HYPERTENSIVE AGENTS, ANTICOAGULANTS; CARDIOVASCULAR AND SEXUAL DISORDERS, ANGINA PECTORIS, AND ATHEROSCLEROSIS AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2002-01-01 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180169095-A1 THE USE OF SGC STIMULATORS, SGC ACTIVATORS, ALONE AND COMBINATIONS WITH PDE5 INHIBITORS FOR THE TREATMENT OF DIGITAL ULCERS (DU) CONCOMITANT TO SYSTEMIC SCLEROSIS (SSC) PDE5A, PDE2A, PDE3A ALDH1A1 3223/4885KDM4E 1029/4885MEN1 4593/4885
US-20100144864-A1 SOLUBLE GUANYLATE CYCLASE (SGC) MODULATORS FOR TREATMENT OF LIPID RELATED DISORDERS GUCY1A2, GUCY1B2, GUCY1B1 ALDH1A1 1484/4885KDM4E 3641/4885MEN1 3134/4885
US-20160158233-A1 SGC STIMULATORS OR SGC ACTIVATORS AND PDE5 INHIBITORS IN COMBINATION WITH ADDITIONAL TREATMENT FOR THE THERAPY OF CYSTIC FIBROSIS PDE5A, PDE3A, GMPS ALDH1A1 3812/4885KDM4E 3394/4885MEN1 4334/4885
US-20040186145-A1 Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them GUCY1A1, GUCY1B1, GUCY1A2 ALDH1A1 860/4885KDM4E 4029/4885MEN1 3056/4885
US-20020061887-A1 Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them GUCY1A1, GUCY1B1, GUCY1A2 ALDH1A1 860/4885KDM4E 4029/4885MEN1 3056/4885
US-20080096936-A1 Sulfur substituted sulfonylaminocarboxylic acid N-arylamides, their preparation, their use and pharmaceutical preparations comprising them GUCY1A1, GUCY1A2, GUCY1B1 ALDH1A1 391/4885KDM4E 4232/4885MEN1 2082/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.