Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.51 |
| ▸ | DRD3 | P35462 | 5/20 | 0.49 |
| ▸ | DRD4 | P21917 | 4/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD1 | P21728 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10035644 | 0.97 | TMEM97 (0.50) | TMEM97DRD3DRD4DRD2DRD1 | |
| Hydrochloric Acid SCHEMBL2141208 | 0.96 | TMEM97 (0.49) | TMEM97DRD3DRD4DRD2DRD1 | |
| SCHEMBL8980845 | 0.88 | DRD3 (0.54) | TMEM97DRD3DRD4DRD2DRD1 | |
| Hydrochloric Acid SCHEMBL4228365 | 0.87 | DRD3 (0.54) | TMEM97DRD3DRD4DRD2DRD1 | |
| SCHEMBL8980784 | 0.87 | DRD3 (0.54) | TMEM97DRD3DRD4DRD2DRD1 | |
| Hydrochloric Acid SCHEMBL4222951 | 0.86 | DRD3 (0.53) | TMEM97DRD3DRD4DRD2DRD1 | |
| SCHEMBL8983817 | 0.86 | HTR7 (0.60) | DRD3DRD2 | |
| SCHEMBL8981292 | 0.85 | HTR7 (0.55) | TMEM97DRD3DRD4DRD2DRD1 | |
| SCHEMBL10035556 | 0.85 | CCR1 (0.53) | TMEM97DRD3DRD4DRD2DRD1 | |
| SCHEMBL8982513 | 0.85 | KMT2A (0.57) | TMEM97DRD3DRD4DRD2DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188115-B2 | 5-HT7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-05-29 | — | — | US | disclosed |
| US-8188115-B2 | 5-HT7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-05-29 | — | — | US | disclosed |
| US-8188115-B2 | 5-HT7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2012-05-29 | — | — | US | disclosed |
| US-20090163542-A1 | 5-ht7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-06-25 | — | — | US | disclosed |
| US-20090163542-A1 | 5-ht7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-06-25 | — | — | US | disclosed |
| US-20090163542-A1 | 5-ht7 receptor antagonists | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-06-25 | — | — | US | disclosed |
| US-20060040978-A1 | 5-HT7 receptor antagonists | LABORATORIES DEL DR. ESTEVE, S.A. (ES) | 2006-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163542-A1 | 5-ht7 receptor antagonists | HTR7, HTR1A, HTR5A | TMEM97 100/4885DRD3 122/4885DRD4 101/4885 |
| US-20060040978-A1 | 5-HT7 receptor antagonists | HTR7, HTR1A, HTR5A | TMEM97 100/4885DRD3 122/4885DRD4 101/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.