Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPA3 | P15088 | 3/20 | 0.62 |
| ▸ | CPA1 | P15085 | 2/20 | 0.62 |
| ▸ | CPB1 | P15086 | 1/20 | 0.62 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | MIF | P14174 | 1/20 | 0.51 |
| ▸ | ALPI | P09923 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | XIAP | P98170 | 1/20 | 0.50 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 2/20 | 0.47 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.47 |
| ▸ | PAM | P19021 | 1/20 | 0.47 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4223751 | 1.00 | CPA3 (0.62) | CPA3CPA1CPB1CPB2CYP1A2 | |
| SCHEMBL4469506 | 0.81 | EPHX1 (0.55) | CPA3CPA1CPB1CPB2CYP1A2 | |
| SCHEMBL5081348 | 0.80 | CPA3 (0.64) | CPA3CPA1CPB1CPB2CYP1A2 | |
| SCHEMBL5081346 | 0.80 | CPA3 (0.64) | CPA3CPA1CPB1CPB2CYP1A2 | |
| SCHEMBL6176552 | 0.80 | CPA3 (0.64) | CPA3CPA1CPB1CPB2CYP1A2 | |
| SCHEMBL11460484 | 0.80 | CPA3 (0.64) | CPA3CPA1CPB1CPB2CYP1A2 | |
| SCHEMBL10535065 | 0.78 | TRPA1 (0.65) | CPA3CPA1CPB1CPB2CYP1A2 | |
| SCHEMBL6138407 | 0.78 | TRPA1 (0.65) | CPA3CPA1CPB1CPB2CYP1A2 | |
| SCHEMBL4315598 | 0.78 | CPA1 (0.62) | CPA3CPA1CPB1CPB2CYP1A2 | |
| SCHEMBL1861755 | 0.78 | TRPA1 (0.65) | CPA3CPA1CPB1CPB2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856083-A4 | CHROMEN-4-ONE INHIBITORS OF ANTI-APOPTOTIC BCL-2 FAMILY MEMBERS AND THE USES THEREOF | UNIV MICHIGAN (US) | 2009-05-27 | — | — | EP | disclosed |
| EP-1856083-A2 | CHROMEN-4-ONE INHIBITORS OF ANTI-APOPTOTIC BCL-2 FAMILY MEMBERS AND THE USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2007-11-21 | — | — | EP | disclosed |
| US-20060247305-A1 | Chromen-4-one inhibitors of anti-apoptotic Bcl-2 family members and the uses thereof | REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2006-11-02 | — | — | US | disclosed |
| WO-2006099193-A2 | CHROMEN-4-ONE INHIBITORS OF ANTI-APOPTOTIC BCL-2 FAMILY MEMBERS AND THE USES THEREOF | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2006-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060247305-A1 | Chromen-4-one inhibitors of anti-apoptotic Bcl-2 family members and the uses thereof | BCL2, BAD, BAX | CPA3 4313/4885CPA1 3468/4885CPB1 852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.