Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.48 |
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 3/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.55 |
| ▸ | CA2 | P00918 | 1/20 | 0.55 |
| ▸ | CA7 | P43166 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.55 |
| ▸ | AGXT | P21549 | 2/20 | 0.52 |
| ▸ | LTA4H | P09960 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4187515 | 0.97 | IDO1 (0.58) | IDO1CA12CA1CA2CA7 | |
| Hydrochloric Acid SCHEMBL5608519 | 0.95 | IDO1 (0.56) | IDO1CA12CA1CA2CA7 | |
| Phosphine SCHEMBL27570532 | 0.95 | IDO1 (0.56) | IDO1CA12CA1CA2CA7 | |
| SCHEMBL18016592 | 0.78 | IDO1 (0.61) | IDO1CA12CA1CA2CA7 | |
| SCHEMBL16760161 | 0.78 | TAAR1 (0.61) | IDO1CA12CA1CA2CA7 | |
| Bromide SCHEMBL28187052 | 0.77 | IDO1 (0.58) | IDO1CA12CA1CA2CA7 | |
| Bromide SCHEMBL3932757 | 0.77 | IDO1 (0.58) | IDO1CA12CA1CA2CA7 | |
| SCHEMBL25986524 | 0.76 | LTA4H (0.81) | IDO1CA12CA1CA2CA7 | |
| SCHEMBL27884 | 0.76 | LTA4H (0.81) | IDO1CA12CA1CA2CA7 | |
| SCHEMBL1425001 | 0.76 | LTA4H (0.81) | IDO1CA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9790241-B2 | Reagent for enhancing generation of chemical species | Toyo Goesi Co., Ltd. (JP) | 2017-10-17 | — | — | US | disclosed |
| US-20160145274-A1 | REAGENT FOR ENHANCING GENERATION OF CHEMICAL SPECIES | TOYO GOSEI CO., LTD. (JP) | 2016-05-26 | — | — | US | disclosed |
| WO-2014208104-A1 | REAGENT FOR ENHANCING GENERATION OF CHEMICAL SPECIES | TOYO GOSEI CO., LTD. (JP) | 2014-12-31 | — | — | WO | disclosed |
| US-7560491-B2 | Z-stilbenes derivatives and the pharmaceutical composition thereof | TAIPEI MEDICAL UNIVERSITY (TW) | 2009-07-14 | — | — | US | disclosed |
| US-20080096973-A1 | Z-stilbenes derivatives and the pharmaceutical composition thereof | TAIPEI MEDICAL UNIVERSITY (TW) | 2008-04-24 | — | — | US | disclosed |
| US-7265105-B2 | Pyrrolobenzodiazepines | SPIROGEN LIMITED (GB) | 2007-09-04 | — | — | US | disclosed |
| US-20060148788-A1 | Pyrrolobenzodiazepines | SPIROGEN LIMITED (GB) | 2006-07-06 | — | — | US | disclosed |
| US-7067511-B2 | Pyrrolobenzodiazepines | SPIROGEN LIMITED (GB) | 2006-06-27 | — | — | US | disclosed |
| US-7049311-B1 | Pyrrolbenzodiazepines | SPIROGEN LIMITED (GB) | 2006-05-23 | — | — | US | disclosed |
| EP-1109812-B1 | PYRROLOBENZODIAZEPINES | SPIROGEN LTD (GB) | 2005-05-04 | — | — | EP | disclosed |
| EP-1413582-A1 | Dimeric pyrrolobenzodiazepines | Spirogen Limited (GB) | 2004-04-28 | — | — | EP | disclosed |
| US-20030120069-A1 | Pyrrolobenzodiazepines | SPIROGEN LIMITED (GB) | 2003-06-26 | — | — | US | disclosed |
| EP-1193270-A2 | Pyrrolobenzodiazepines | Spirogen Limited (GB) | 2002-04-03 | — | — | EP | disclosed |
| EP-1109812-A2 | PYRROLOBENZODIAZEPINES | Spirogen Limited (GB) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012508-A2 | PYRROLBENZODIAZEPINES | SPIROGEN LIMITED (GB) | 2000-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160145274-A1 | REAGENT FOR ENHANCING GENERATION OF CHEMICAL SPECIES | CYBB, PPOX, GPX4 | SLC6A4 4197/4885ACHE 1438/4885IDO1 3159/4885 |
| US-20060148788-A1 | Pyrrolobenzodiazepines | HCRTR2, MCHR2, CHRM5 | SLC6A4 3775/4885ACHE 2931/4885IDO1 2079/4885 |
| US-20080096973-A1 | Z-stilbenes derivatives and the pharmaceutical composition thereof | CCNB1, ZYX, H1-0 | SLC6A4 1484/4885ACHE 4159/4885IDO1 1118/4885 |
| US-20030120069-A1 | Pyrrolobenzodiazepines | CNR1, CBX2, CNR2 | SLC6A4 3310/4885ACHE 4345/4885IDO1 923/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.