Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.47 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.47 |
| ▸ | PRKCG | P05129 | 3/20 | 0.47 |
| ▸ | PRKCB | P05771 | 3/20 | 0.47 |
| ▸ | SRC | P12931 | 3/20 | 0.47 |
| ▸ | PRKCA | P17252 | 3/20 | 0.47 |
| ▸ | PRKCH | P24723 | 3/20 | 0.47 |
| ▸ | PRKCI | P41743 | 3/20 | 0.47 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.47 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.47 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | ABL2 | P42684 | 1/20 | 0.47 |
| ▸ | PPOX | P50336 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | BCL2 | P10415 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.44 |
| ▸ | BRAF | P15056 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24414673 | 0.83 | KDM4E (0.52) | EGFRPRKD3PRKCGPRKCBSRC | |
| SCHEMBL38656398 | 0.79 | CA1 (0.44) | EGFRPRKD3PRKCGPRKCBSRC | |
| SCHEMBL8650681 | 0.75 | HMGCR (0.46) | PRKCIGSK3BTDP1MEN1MAPT | |
| SCHEMBL30828317 | 0.74 | MAOA (0.56) | EGFRPRKD3PRKCGPRKCBSRC | |
| SCHEMBL177986 | 0.74 | MAOA (0.56) | EGFRPRKD3PRKCGPRKCBSRC | |
| SCHEMBL1081926 | 0.73 | GRM5 (0.55) | EGFRPRKD3PRKCGPRKCBSRC | |
| SCHEMBL15638608 | 0.72 | CES1 (0.57) | EGFRBCL2MCL1TDP1MAPT | |
| SCHEMBL15680364 | 0.71 | PPOX (0.42) | PPOXGSK3BBCL2MCL1PTGS2 | |
| SCHEMBL8821657 | 0.71 | BCL2 (0.74) | BCL2MCL1TDP1CYP3A4MEN1 | |
| SCHEMBL28805663 | 0.71 | BCL2 (0.46) | EGFRPRKD3PRKCGPRKCBSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009026248-A2 | HYDRAZIDE, AMIDE, PHTHALIMIDE AND PHTHALHYDRAZIDE ANALOGS AS INHIBITORS OF RETROVIRAL INTEGRASE | THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF HEALTH AND HUMAN SERVICES, NATIONAL INSTITUTES OF HEALTH, OFFICE OF TECHNOLOGY TRANSFER (US) | 2009-02-26 | — | — | WO | disclosed |
| EP-0412763-B1 | Cephalosporins, processes for their preparation, pharmaceutical compositions containing them and intermediates therefor | ZENECA LTD (GB) | 1996-07-10 | — | — | EP | disclosed |
| US-5219848-A | Bactericides | ICI PHARMA (FR) | 1993-06-15 | — | — | US | disclosed |