SCHEMBL422660

SCHEMBL422660

Oc1c(Cl)cc(Cl)cc1I

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 6/20 0.65
TSHR P16473 5/20 0.65
ALDH1A1 P00352 4/20 0.65
CYP3A4 P08684 2/20 0.65
RECQL P46063 2/20 0.65
TTR P02766 3/20 0.50
HPGD P15428 3/20 0.50
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
THRB P10828 2/20 0.50
MAPK1 P28482 2/20 0.50
ALOX15 P16050 2/20 0.50
ALOX12 P18054 2/20 0.50
SMN1; SMN2 Q16637 2/20 0.50
HIF1A Q16665 2/20 0.50
KDM4E B2RXH2 1/20 0.50
SLC22A2 O15244 1/20 0.50
SLC22A1 O15245 1/20 0.50
NR1I2 O75469 1/20 0.50
SLC22A3 O75751 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7926703 0.86 TTR (0.58) HSD17B10TSHRALDH1A1CYP3A4RECQL
SCHEMBL184648 0.80 HSD17B10 (1.00) HSD17B10TSHRALDH1A1CYP3A4RECQL
SCHEMBL8872103 0.80 HSD17B10 (1.00) HSD17B10TSHRALDH1A1CYP3A4RECQL
SCHEMBL7932590 0.79 TTR (0.65) HSD17B10TSHRALDH1A1CYP3A4RECQL
SCHEMBL2808115 0.77 HSD17B10 (0.93) HSD17B10TSHRALDH1A1CYP3A4RECQL
SCHEMBL28244966 0.77 HSD17B10 (0.93) HSD17B10TSHRALDH1A1CYP3A4RECQL
SCHEMBL11291920 0.77 HSD17B10 (0.93) HSD17B10TSHRALDH1A1CYP3A4RECQL
SCHEMBL20380030 0.77 HSD17B10 (0.93) HSD17B10TSHRALDH1A1CYP3A4RECQL
SCHEMBL29827111 0.77 HSD17B10 (0.93) HSD17B10TSHRALDH1A1CYP3A4RECQL
SCHEMBL723100 0.77 TTR (0.48) HSD17B10TSHRALDH1A1CYP3A4RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114113370-A Analysis method of aromatic halogenated disinfection byproducts in water 东南大学 2022-03-01 CN claimed
EP-1155073-A1 PLASTIC MOULDING MATERIALS WHICH CAN BE DETECTED BY X-RAY CONTRAST Bayer Aktiengesellschaft (DE) 2001-11-21 EP claimed
WO-2000036002-A1 PLASTIC MOULDING MATERIALS WHICH CAN BE DETECTED BY X-RAY CONTRAST BAYER AKTIENGESELLSCHAFT (DE) 2000-06-22 WO claimed
US-12466781-B2 Thyromimetics AUTOBAHN THERAPEUTICS, INC. (US) 2025-11-11 US disclosed
EP-4598901-A1 PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF Thomas Jefferson University (US) 2025-08-13 EP disclosed
CN-114163421-B Novel heterocyclic compound and organic light-emitting device comprising same 株式会社LG化学 2024-09-03 CN disclosed
WO-2024076964-A1 PYRROLIDINE AND IMIDAZOLIDINE BASED DNA POLYMERASE THETA INHIBITORS AND USE THEREOF THOMAS JEFFERSON UNIVERSITY (US) 2024-04-11 WO disclosed
CN-114113370-B Analysis method of aromatic halogenated disinfection byproducts in water 东南大学 2024-03-26 CN disclosed
US-20240027902-A1 CHEMICALLY AMPLIFIED RESIST COMPOSITION AND PATTERNING PROCESS SHIN-ETSU CHEMICAL CO., LTD. (JP) 2024-01-25 US disclosed
US-20240027902-A1 CHEMICALLY AMPLIFIED RESIST COMPOSITION AND PATTERNING PROCESS SHIN-ETSU CHEMICAL CO., LTD. (JP) 2024-01-25 US disclosed
US-11835860-B2 Resist composition and patterning process SHIN-ETSU CHEMICAL CO., LTD. (JP) 2023-12-05 US disclosed
US-20030171428-A1 Substituted 2-phenyl benzofurans as estrogenic agents WYETH 2003-09-11 US disclosed
WO-2003051860-A2 SUBSTITUTED 2-PHENYL BENZOFURANS AS ESTROGENIC AGENTS WYETH (US) 2003-06-26 WO disclosed
US-6509406-B1 X-ray contrastable plastic materials comprising 0.1 wt. % to 25 wt. % of 4,4'-diiodobiphenyl. BAYER AKTIENGESELLSCHAFT (DE) 2003-01-21 US disclosed
EP-0443533-B1 Positive photoresist composition FUJI PHOTO FILM CO LTD (JP) 1998-09-30 EP disclosed
US-5420310-A Anticoagulants, antiulcer, antiatherosclerosis agents formed in multistage reaction TORAY INDUSTRIES, INC. (JP) 1995-05-30 US disclosed
EP-0463162-B1 PREPARATION OF 5,6,7-TRINOR-4,8-INTER-m-PHENYLENE PGI 2 DERIVATIVES TORAY INDUSTRIES (JP) 1994-05-11 EP disclosed
US-5202447-A Stereospecific TORAY INDUSTRIES, INC. (JP) 1993-04-13 US disclosed
EP-0463162-A1 PREPARATION OF 5,6,7-TRINOR-4,8-INTER-m-PHENYLENE PGI 2 DERIVATIVES TORAY INDUSTRIES, INC. (JP) 1992-01-02 EP disclosed
EP-0443533-A2 Positive photoresist composition FUJI PHOTO FILM CO., LTD. (JP) 1991-08-28 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12466781-B2 Thyromimetics TPO, TSHR, CHRM1 HSD17B10 1760/4885TSHR 2/4885ALDH1A1 1070/4885
US-20030171428-A1 Substituted 2-phenyl benzofurans as estrogenic agents ESR1, ESR2, GPER1 HSD17B10 1151/4885TSHR 189/4885ALDH1A1 505/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.