Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 2/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 5/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4233242 | 0.95 | METAP1 (0.49) | METAP1ADORA2AUTS2RL3MBTL1NPC1 | |
| SCHEMBL3231734 | 0.89 | UTS2R (0.42) | METAP1UTS2RMAPK1 | |
| SCHEMBL1482834 | 0.89 | METAP1 (0.45) | METAP1ADORA2AUTS2RL3MBTL1NPC1 | |
| SCHEMBL3215252 | 0.89 | UTS2R (0.39) | METAP1UTS2RL3MBTL1NPC1RAB9A | |
| SCHEMBL3222714 | 0.87 | UTS2R (0.39) | METAP1UTS2R | |
| SCHEMBL4229384 | 0.87 | ROCK2 (0.43) | UTS2RLMNA | |
| SCHEMBL4233301 | 0.87 | METAP1 (0.45) | METAP1ADORA2A | |
| SCHEMBL2384055 | 0.87 | HDAC3 (0.41) | METAP1ADORA2AUTS2RL3MBTL1NPC1 | |
| SCHEMBL3226314 | 0.86 | UTS2R (0.42) | UTS2RL3MBTL1NPC1MEN1KMT2A | |
| SCHEMBL3234631 | 0.85 | NAMPT (0.42) | UTS2RNPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2135620-A1 | OCULAR HYPOTENSIVE AGENT COMPRISING COMPOUND CAPABLE OF INHIBITING HISTONE DEACETYLASE AS ACTIVE INGREDIENT | Santen Pharmaceutical Co., Ltd (JP) | 2009-12-23 | — | — | EP | disclosed |
| EP-2133339-A1 | NOVEL (2-AMINOPHENYL)PYRIDINECARBOXAMIDE DERIVATIVE HAVING UREA STRUCTURE | Santen Pharmaceutical Co., Ltd (JP) | 2009-12-16 | — | — | EP | disclosed |