Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | UBE2M | P61081 | 1/20 | 0.38 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 9/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4229354 | 0.96 | METAP1 (0.46) | METAP1HRH1UBE2MDCUN1D1KCNA5 | |
| SCHEMBL4224157 | 0.94 | CASR (0.43) | METAP1HRH1UBE2MDCUN1D1KCNA5 | |
| SCHEMBL4376286 | 0.93 | METAP1 (0.44) | METAP1HRH1UBE2MDCUN1D1KCNA5 | |
| SCHEMBL4234586 | 0.92 | CASR (0.43) | METAP1HRH1UBE2MDCUN1D1KCNA5 | |
| SCHEMBL4229846 | 0.88 | HRH1 (0.40) | HRH1UBE2MDCUN1D1KCNA5ALDH1A1 | |
| SCHEMBL3231643 | 0.87 | CSF1R (0.38) | ABL1SRC | |
| SCHEMBL4227705 | 0.87 | METAP1 (0.47) | METAP1ADORA2A | |
| SCHEMBL4233242 | 0.85 | METAP1 (0.49) | METAP1ADORA2A | |
| SCHEMBL2477400 | 0.85 | CYP2D6 (0.48) | METAP1ADORA2AALDH1A1CASR | |
| SCHEMBL3225124 | 0.84 | LMNA (0.40) | ABL1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2135620-A1 | OCULAR HYPOTENSIVE AGENT COMPRISING COMPOUND CAPABLE OF INHIBITING HISTONE DEACETYLASE AS ACTIVE INGREDIENT | Santen Pharmaceutical Co., Ltd (JP) | 2009-12-23 | — | — | EP | disclosed |
| EP-2133339-A1 | NOVEL (2-AMINOPHENYL)PYRIDINECARBOXAMIDE DERIVATIVE HAVING UREA STRUCTURE | Santen Pharmaceutical Co., Ltd (JP) | 2009-12-16 | — | — | EP | disclosed |