Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 11/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 11/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4219387 | 0.88 | HDAC3 (0.47) | ROCK2ROCK1MAPTHDAC3HDAC1 | |
| SCHEMBL4227705 | 0.87 | METAP1 (0.47) | UTS2RLMNA | |
| SCHEMBL4377779 | 0.87 | UTS2R (0.52) | ROCK2ROCK1UTS2R | |
| SCHEMBL3222714 | 0.84 | UTS2R (0.39) | ROCK2ROCK1HDAC1UTS2R | |
| SCHEMBL3215252 | 0.84 | UTS2R (0.39) | ROCK2ROCK1MAPTUTS2R | |
| SCHEMBL3231734 | 0.84 | UTS2R (0.42) | ROCK2ROCK1UTS2R | |
| SCHEMBL3226314 | 0.83 | UTS2R (0.42) | ROCK2ROCK1UTS2RLMNA | |
| SCHEMBL4229327 | 0.82 | LMNA (0.39) | MAPTUTS2RLMNA | |
| SCHEMBL4233242 | 0.82 | METAP1 (0.49) | ROCK2ROCK1UTS2RLMNA | |
| SCHEMBL4229370 | 0.82 | MAPT (0.43) | ROCK2ROCK1MAPTHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2135620-A1 | OCULAR HYPOTENSIVE AGENT COMPRISING COMPOUND CAPABLE OF INHIBITING HISTONE DEACETYLASE AS ACTIVE INGREDIENT | Santen Pharmaceutical Co., Ltd (JP) | 2009-12-23 | — | — | EP | disclosed |
| EP-2133339-A1 | NOVEL (2-AMINOPHENYL)PYRIDINECARBOXAMIDE DERIVATIVE HAVING UREA STRUCTURE | Santen Pharmaceutical Co., Ltd (JP) | 2009-12-16 | — | — | EP | disclosed |