⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5035600 | 1.00 | — | — | |
| SCHEMBL7086501 | 0.70 | NLRP3 (0.41) | — | |
| SCHEMBL7044618 | 0.67 | — | — | |
| SCHEMBL7044502 | 0.67 | — | — | |
| SCHEMBL12805379 | 0.66 | TSHR (0.45) | — | |
| SCHEMBL6368632 | 0.64 | — | — | |
| SCHEMBL13992886 | 0.63 | — | — | |
| SCHEMBL7064079 | 0.63 | PKM (0.30) | — | |
| SCHEMBL9371202 | 0.63 | — | — | |
| SCHEMBL18022313 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160237101-A9 | IMIDAZOLIDINE-BASED METAL CARBENE METATHESIS CATALYSTS | NATIONAL INSTITUTES OF HEALTH | 2016-08-18 | — | — | US | disclosed |
| US-20150038724-A1 | IMIDAZOLIDINE-BASED METAL CARBENE METATHESIS CATALYSTS | CALIFORNIA INST OF TECHN (US) | 2015-02-05 | — | — | US | disclosed |
| US-8846939-B2 | Imidazolidine-based metal carbene metathesis catalysts | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2014-09-30 | — | — | US | disclosed |
| US-20130165661-A1 | IMIDAZOLIDINE-BASED METAL CARBENE METATHESIS CATALYSTS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2013-06-27 | — | — | US | disclosed |
| US-20090022764-A1 | ORGANIC COMPOUNDS | GIVAUDAN SA (CH) | 2009-01-22 | — | — | US | disclosed |
| US-20080132708-A1 | An osmium or ruthenium carbene (dichlorobis(tricyclohexylphosphine)ruthenium phenylcarbene) reacted with a 2-alkoxy- or aryloxyimidazolidene; improved catalyst selectivity in all types of metathesis reactions | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2008-06-05 | — | — | US | disclosed |
| US-7329758-B1 | Prepared by reacting an osmium or ruthenium carbene (dichlorobis(tricyclohexylphosphine)ruthenium phenylcarbene) with a 2-alkoxy- or aryloxyimidazolidene; ring-closing metathesis of an acyclic olefin (diethyl diallylmalonate) to form a cycloolefin (diethyl tetramethylenemalonate) | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2008-02-12 | — | — | US | disclosed |
| EP-1788871-A1 | ROMP POLYMER PARTICLES COMPRISING ACTIVE INGREDIENTS | Givaudan SA (CH) | 2007-05-30 | — | — | EP | disclosed |
| WO-2006024184-A1 | ROMP POLYMER PARTICLES COMPRISING ACTIVE INGREDIENTS | GIVAUDAN SA (CH) | 2006-03-09 | — | — | WO | disclosed |
| EP-1180108-B1 | IMIDAZOLIDINE-BASED METAL CARBENE METATHESIS CATALYSTS | CALIFORNIA INST OF TECHN (US) | 2003-08-27 | — | — | EP | disclosed |
| EP-1180108-A2 | IMIDAZOLIDINE-BASED METAL CARBENE METATHESIS CATALYSTS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2002-02-20 | — | — | EP | disclosed |
| WO-2000071554-A2 | IMIDAZOLIDINE-BASED METAL CARBENE METATHESIS CATALYSTS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2000-11-30 | — | — | WO | disclosed |